TY  - BOOK
AU  - Beyene, Solomon
AU  - Garcia-Garcia, Hector M
AU  - Hideo-Kajita, Alexandre
AU  - Kolm, Paul
AU  - Kuku, Kayode
AU  - Ozaki, Yuichi
AU  - Waksman, Ron
TI  - Effect of Statin Therapy on Fibrous Cap Thickness in Coronary Plaque on Optical Coherence Tomography - Review and Meta-Analysis
SN  - 1346-9843
PY  - 2019///
KW  - *Coronary Artery Disease
KW  - *Hydroxymethylglutaryl-CoA Reductase Inhibitors/tu [Therapeutic Use]
KW  - *Plaque, Atherosclerotic
KW  - *Tomography, Optical Coherence
KW  - Coronary Artery Disease/dg [Diagnostic Imaging]
KW  - Coronary Artery Disease/dt [Drug Therapy]
KW  - Female
KW  - Humans
KW  - Male
KW  - Observational Studies as Topic
KW  - Plaque, Atherosclerotic/dg [Diagnostic Imaging]
KW  - Plaque, Atherosclerotic/dt [Drug Therapy]
KW  - Randomized Controlled Trials as Topic
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
N2  - BACKGROUND: Statin therapy has been shown to result in coronary plaque regression, but the relationship between statin use and stabilization of coronary plaque has not been elucidated. We conducted a systematic review and meta-analysis to evaluate the effect of statin therapy on fibrous cap thickness (FCT) on optical coherence tomography (OCT).Methods and Results:Nine OCT studies (6 randomized controlled trials and 3 observational studies) were enrolled with a total of 341 patients (390 lesions). Arms of the studies were grouped according to statin type and/or dose. Random effects meta-analysis was used to estimate a pooled mean change in FCT from baseline to follow-up. The overall effect mean FCT change was 67.7 micro m (95% CI: 51.4-84.1, I<sup>2</sup>=95.0%, P<0.001). All statin groups had an increase in FCT, but the magnitude of the increase differed according to the statin. Two homogeneous subgroups with I<sup>2</sup>=0 were identified: mean FCT change was 27.8 micro m (for subgroup atorvastatin 5 mg and rosuvastatin), and 61.9 micro m (for subgroup atorvastatin 20 mg, fluvastatin 30 mg, and pitavastatin 4 mg). On meta-regression modeling, statin therapy alone explained most of the change in FCT; CONCLUSIONS: Statin therapy induced a significant increase in FCT as assessed on OCT, independent of coronary risk factors and other medications
UR  - https://dx.doi.org/10.1253/circj.CJ-18-1376
ER  -