03019nam a22005177a 4500
190827s20212021 xxu||||| |||| 00| 0 eng d
0735-1631
10.1055/s-0039-1694730 [doi]
Ovid MEDLINE(R)
31412405
Respiratory and Hemodynamic Changes in Neonates with Hypoxic-Ischemic Encephalopathy during and after Whole-Body Hypothermia.
American Journal of Perinatology. 38(1):37-43, 2021 01.
Am J Perinatol. 38(1):37-43, 2021 01.
Am J Perinatol. 2019 Aug 14
American journal of perinatology
2021
FY2021
aheadofprint
ppublish
2019-08-27
American Journal of Perinatology. 2019 Aug 14
FY2020
CONCLUSION: There was a decrease in metabolic demand as measured by oxygen requirement, OI, HR, and MBP during WBH, but only HR increased during rewarming, with no significant change in the other parameters. Some of this effect may be explained by improvement in the respiratory condition over time.
Copyright Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
OBJECTIVE: To determine the degree to which whole-body hypothermia (WBH) impacts hemodynamic and respiratory status during hypothermia and the subsequent rewarming period in neonates with hypoxic-ischemic encephalopathy (HIE).
RESULTS: HR decreased during WBH and significantly increased during rewarming. Lactate level, OI, VEI, FiO<sub>2</sub>, and MBP all decreased during WBH but showed no significant change during and after rewarming.
STUDY DESIGN: This is a retrospective study reviewing the medical records of infants treated with WBH. Data including oxygenation index (OI), ventilator efficiency index (VEI), fraction of inspired oxygen (FiO<sub>2</sub>), blood lactate level, heart rate (HR), and mean blood pressure (MBP) were collected from defined time points from the beginning, middle, and end of WBH and then every 2 hours from the beginning of rewarming for 14 hours thereafter. The analysis included 65 infants. Data were analyzed using a piecewise linear regression with a mixed-effect model.
English
*Hemodynamics
*Hypothermia, Induced
*Hypoxia-Ischemia, Brain/pp [Physiopathology]
*Respiration
Humans
Hypoxia-Ischemia, Brain/th [Therapy]
Infant, Newborn
Linear Models
Oxygen Consumption/ph [Physiology]
Oxygen/bl [Blood]
Retrospective Studies
MedStar Heart & Vascular Institute
Journal Article
Desale, Sameer
Abubakar K, Desale S, Sheppard SR
https://dx.doi.org/10.1055/s-0039-1694730
https://dx.doi.org/10.1055/s-0039-1694730
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Article
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Article
authcat
authcat
2019-08-27
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31412405
31412405
2019-08-27
2019-08-27
ART
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4545