TY  - BOOK
AU  - Chang, Jason
TI  - Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed
SN  - 2328-9503
PY  - 2019///
KW  - *Anticoagulants/tu [Therapeutic Use]
KW  - *Cerebral Hemorrhage/dt [Drug Therapy]
KW  - *Vitamin K/tu [Therapeutic Use]
KW  - Administration, Oral
KW  - Aged
KW  - Aged, 80 and over
KW  - Cohort Studies
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Prevalence
KW  - Retrospective Studies
KW  - Stroke
KW  - Vitamin K/ai [Antagonists & Inhibitors]
KW  - MedStar Washington Hospital Center
KW  - Surgical Critical Care
KW  - Journal Article
N2  - Copyright (c) 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association; Prior studies suggest an association between Vitamin K antagonists (VKA) and cerebral microbleeds (CMBs); less is known about nonvitamin K oral anticoagulants (NOACs). In this observational study we describe CMB profiles in a multicenter cohort of 89 anticoagulation-related intracerebral hemorrhage (ICH) patients. CMB prevalence was 51% (52% in VKA-ICH, 48% in NOAC-ICH). NOAC-ICH patients had lower median CMB count [2(IQR:1-3) vs. 7(4-11); P < 0.001]; >=5 CMBs were less prevalent in NOAC-ICH (4% vs. 31%, P = 0.006). This inverse association between NOAC exposure and high CMB count persisted in multivariable logistic regression models adjusting for potential confounders (OR 0.10, 95%CI: 0.01-0.83; P = 0.034)
UR  - https://dx.doi.org/10.1002/acn3.50834
ER  -