TY  - BOOK
AU  - Lacey, Elizabeth H
AU  - Turkeltaub, Peter E
TI  - Dissociable Mechanisms of Verbal Working Memory Revealed through Multivariate Lesion Mapping
SN  - 1047-3211
PY  - 2020///
KW  - *Brain Mapping/mt [Methods]
KW  - *Memory, Short-Term/ph [Physiology]
KW  - *Stroke/dg [Diagnostic Imaging]
KW  - *Temporal Lobe/dg [Diagnostic Imaging]
KW  - *Temporal Lobe/ph [Physiology]
KW  - *Verbal Learning/ph [Physiology]
KW  - Aged
KW  - Female
KW  - Humans
KW  - Image Processing, Computer-Assisted/mt [Methods]
KW  - Magnetic Resonance Imaging/mt [Methods]
KW  - Male
KW  - Middle Aged
KW  - Stroke/px [Psychology]
KW  - MedStar National Rehabilitation Network
KW  - Journal Article
KW  - Research Support, N.I.H., Extramural
KW  - Research Support, Non-U.S. Gov't
N2  - Two maintenance mechanisms with separate neural systems have been suggested for verbal working memory: articulatory-rehearsal and non-articulatory maintenance. Although lesion data would be key to understanding the essential neural substrates of these systems, there is little evidence from lesion studies that the two proposed mechanisms crucially rely on different neuroanatomical substrates. We examined 39 healthy adults and 71 individuals with chronic left-hemisphere stroke to determine if verbal working memory tasks with varying demands would rely on dissociable brain structures. Multivariate lesion-symptom mapping was used to identify the brain regions involved in each task, controlling for spatial working memory scores. Maintenance of verbal information relied on distinct brain regions depending on task demands: sensorimotor cortex under higher demands and superior temporal gyrus (STG) under lower demands. Inferior parietal cortex and posterior STG were involved under both low and high demands. These results suggest that maintenance of auditory information preferentially relies on auditory-phonological storage in the STG via a nonarticulatory maintenance when demands are low. Under higher demands, sensorimotor regions are crucial for the articulatory rehearsal process, which reduces the reliance on STG for maintenance. Lesions to either of these regions impair maintenance of verbal information preferentially under the appropriate task conditions. Copyright (c) The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
UR  - https://dx.doi.org/10.1093/cercor/bhz259
ER  -