TY  - BOOK
AU  - Howard, Barbara V
AU  - Umans, Jason G
TI  - Plasma Ceramide Species Are Associated with Diabetes Risk in Participants of the Strong Heart Study
SN  - 0022-3166
PY  - 2020///
KW  - *Ceramides/bl [Blood]
KW  - *Diabetes Mellitus, Type 2/bl [Blood]
KW  - *Indians, North American
KW  - Adult
KW  - Aged
KW  - Arizona
KW  - Case-Control Studies
KW  - Ceramides/ch [Chemistry]
KW  - Diabetes Mellitus, Type 2/eh [Ethnology]
KW  - Female
KW  - Follow-Up Studies
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - North Dakota
KW  - Oklahoma
KW  - Prospective Studies
KW  - Risk Factors
KW  - South Dakota
KW  - Sphingolipids/bl [Blood]
KW  - Sphingomyelins/bl [Blood]
KW  - MedStar Health Research Institute
KW  - Journal Article
N1  - Available online from MWHC library: Sept 1928 - present (after 1 year)
N2  - BACKGROUND: Few studies have assessed the associations of ceramides and sphingomyelins (SMs) with diabetes in humans; CONCLUSIONS: Higher concentrations of circulating Cer-18, Cer-20, and Cer-22 were associated with a higher risk of developing diabetes in 2 studies of American-Indian adults. This trial was registered at clinicaltrials.gov as NCT00005134. Copyright (c) The Author(s) 2019; METHODS: The analysis included 435 American-Indian participants from the Strong Heart Study (nested case-control design for analyses; mean age: 57 y; 34% male; median time until diabetes 4.3 y for cases) and 1902 participants from the Strong Heart Family Study (prospective design for analyses; mean age: 37 y; 39% male; median 12.5 y of follow-up). Sphingolipid species were measured using stored plasma samples by sequential LC and MS. Using logistic regression and parametric survival models within studies, and an inverse-variance-weighted meta-analysis across studies, we examined associations of 15 ceramides and SM species with incident diabetes; OBJECTIVE: We assessed associations of 15 circulating ceramides and SM species with incident diabetes in 2 studies; RESULTS: There were 446 cases of incident diabetes across the studies. Higher circulating concentrations of ceramides containing stearic acid (Cer-18), arachidic acid (Cer-20), and behenic acid (Cer-22) were each associated with a higher risk of diabetes. The RRs for incident diabetes per 1 SD of each log ceramide species (muM) were 1.22 (95% CI: 1.09, 1.37) for Cer-18, 1.18 (95% CI: 1.06, 1.31) for Cer-20, and 1.20 (95% CI: 1.08, 1.32) for Cer-22. Although the magnitude of the risk estimates for the association of ceramides containing lignoceric acid (Cer-24) with diabetes was similar to those for Cer-18, Cer-20, and Cer-22 (RR = 1.13; 95% CI: 1.01, 1.26), the association was not statistically significant after correction for multiple testing (P = 0.007). Ceramides carrying palmitic acid (Cer-16), SMs, glucosyl-ceramides, or a lactosyl-ceramide were not associated with diabetes risk
UR  - https://dx.doi.org/10.1093/jn/nxz259
ER  -