TY  - BOOK
AU  - Kirkpatrick, Liam D
AU  - Nisar, Saira
AU  - Shupp, Jeffrey W
TI  - Bacterial Virulence Factors and their Contribution to Pathophysiology after Thermal Injury
SN  - 1096-2964
PY  - 2021///
KW  - *Burns
KW  - *Pseudomonas Infections
KW  - Bacteria
KW  - Burns/co [Complications]
KW  - Humans
KW  - Pseudomonas aeruginosa
KW  - Virulence
KW  - Virulence Factors
KW  - MedStar Health Research Institute
KW  - Firefighters' Burn and Surgical Research Laboratory
KW  - Journal Article
N2  - Background: Bacterial infections are the leading cause of morbidity and mortality in burn-injured patients. Pseudomonas aeruginosa and Staphylococcus aureus are among the most common pathogens responsible for infections in thermally injured patients. These and other pathogens have developed a variety of virulence factors to colonize and infect hosts. Methods: A comprehensive literature review was conducted to best summarize the current knowledge of how virulence factors contribute to bacterial pathogenicity. Results: The review highlights the unique mechanisms bacteria utilize to evade host defense systems and further complicate the treatment of burn-injured patients. Conclusion:  Further research on virulence factors and their contribution to bacterial pathogenicity is warranted and could potentially lead to development of neutralizing pharmacotherapy that would complement antimicrobial treatment
UR  - https://dx.doi.org/10.1089/sur.2020.188
ER  -