Blood pressure during sleep is associated with arterial stiffness and urine microalbumin to creatinine ratio in youth with type 1 diabetes.
- 2020
AIMS: To determine whether sleep blood pressure (BP) is associated with increased cardiovascular disease (CVD) risk in youth with type 1 diabetes (T1DM). CONCLUSIONS: Blood pressure alterations during sleep are common in youth with T1DM and they are associated with arterial stiffness and UAC. Larger studies are needed to confirm our results and examine whether interventions that target sleep and night-time BP could decrease CVD risk. Copyright (c) 2020 Elsevier Inc. All rights reserved. METHODS: We enrolled youth with T1DM, 12-21years old. Carotid-femoral Pulse Wave Velocity (PWVcf) assessed arterial stiffness, a CVD marker. Sleep systolic and diastolic BP variables were obtained from 24-hour BP Monitoring. Linear regression models analyzed the relationship of each BP variable with PWVcf, adjusted for HbA1c. Correlation of sleep BP with urine microalbumin-to-creatinine ratio (UAC) was examined. RESULTS: Nocturnal hypertension was found in 36% and abnormal dipping in 48% of the 25 participants, aged 17.7+/-2.2years old. Sleep systolic BP [beta=0.039, 95% Confidence Interval (CI; 0.006-0.073)], diastolic BP [beta=0.058, 95% CI (0.003-0.114)], Mean Arterial Pressure (MAP) [beta=0.075, 95% CI (0.018-0.131)] and MAP index [beta=3.547, 95% CI (0.867-6.227)] were significantly associated with PWVcf. Sleep diastolic BP, load, MAP correlated with UAC.