03620nam a22004697a 4500
200902s20202020 xxu||||| |||| 00| 0 eng d
1096-2964
10.1089/sur.2020.202 [doi]
Ovid MEDLINE(R)
32716696
Innovations in Infection Prevention and Treatment. [Review]
Surgical Infections. 22(1):12-19, 2021 Feb.
Surg Infect (Larchmt). 22(1):12-19, 2021 Feb.
Surg Infect (Larchmt). 2020 Jul 22
Surgical infections
2021
FY2021
aheadofprint
ppublish
2020-09-02
Surgical Infections. 2020 Jul 22
FY2021
Background: Patients with large, acute burn injuries are a major challenge for clinicians. The loss of skin barrier protection against micro-organisms combined with the induced immunosuppression after burn injury makes this population especially vulnerable to infection. For burn-injured patients who survive immediate management considerations and burn resuscitation after acute injury, sepsis remains the primary cause of death. The purpose of this article is to describe current strategies and innovations in burn sepsis prevention and management. Methods: This work reviews the current understanding of the systemic inflammatory response to burn injury and burn sepsis as well as current strategies in insolation and infection prevention, newer burn unit design strategies in the context of infection prevention, and novel therapies being considered in topical antimicrobial wound care management. Results: A review of burn sepsis is key to understanding current paradigms and innovation in burn management and prevention. Key management principles begin from the time of injury and persist throughout the patient's hospital course. This includes use of personal protective equipment, burn unit design considerations, and knowledge of critical care principles such as central venous catheter management strategies. Innovations on wound dressing types, forms, and use have been key to better controlling burn wound sepsis and improving wound healing. Products incorporating nanotechnology, novel anions, oxygen, and even light have been key to introducing previously unconsidered methods to fight or prevent infection. Conclusion: Understanding the pathophysiology and source identification of sepsis from burn wounds has been a key contributor in developing innovative prevention and therapeutic strategies in burn management. The emergence of drug-resistant pathogens and the difficulty of systemic antibiotic agents to reach poorly vascularized wounds have further reinforced the need to anticipate management strategies moving forward. A proactive, multidisciplinary approach is necessary to minimize the morbidity and mortality associated with infection control.
English
*Anti-Infective Agents
*Sepsis
*Wound Infection
Bandages
Humans
Infection Control
Sepsis/pc [Prevention & Control]
Wound Healing
Wound Infection/pc [Prevention & Control]
MedStar Health Research Institute
Firefighters' Burn and Surgical Research Laboratory
Journal Article
Shupp, Jeffrey W
Tejiram, Shawn
Shupp JW, Tejiram S
https://dx.doi.org/10.1089/sur.2020.202
https://dx.doi.org/10.1089/sur.2020.202
ART
Article
0
0
0
0
Article
authcat
authcat
2020-09-02
0
32716696
32716696
2020-09-02
2020-09-02
ART
5433
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