02556nam a22005057a 4500
200902s20202020 xxu||||| |||| 00| 0 eng d
1757-790X
10.1136/bcr-2020-236009 [doi]
13/7/e236009 [pii]
PMC7389772 [pmc]
Ovid MEDLINE(R)
32723779
Intermittent left bundle branch block and acute heart failure in trastuzumab-induced cardiotoxicity.
BMJ Case Reports. 13(7), 2020 Jul 28.
BMJ Case Rep. 13(7), 2020 Jul 28.
BMJ Case Rep. 13(7), 2020 Jul 28.
BMJ case reports
2020
FY2021
epublish
epublish
2020-09-02
BMJ Case Reports. 13(7), 2020 Jul 28.
A 70-year-old woman with HER2+/ER+ breast cancer on adjuvant trastuzumab therapy without a history of cardiovascular disease presented with respiratory failure from influenza and was found to have intermittent left bundle branch block (LBBB) with new onset systolic heart failure. Her course was complicated by polymorphic ventricular tachycardia and recurrent chest pain. Significant investigations included a normal cardiac MRI and cardiac catheterisation with unobstructed coronaries. It was determined that the aetiology of her heart failure was trastuzumab-induced cardiotoxicity after comprehensive workup. This case highlights an uncommon presentation of LBBB and the steps taken to diagnose a rare cardiomyopathy. Copyright (c) BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.
English
*Antineoplastic Agents, Immunological/ae [Adverse Effects]
*Bundle-Branch Block/ci [Chemically Induced]
*Heart Failure, Systolic/ci [Chemically Induced]
*Trastuzumab/ae [Adverse Effects]
Aged
Breast Neoplasms/ch [Chemistry]
Breast Neoplasms/dt [Drug Therapy]
Bundle-Branch Block/pp [Physiopathology]
Cardiotoxicity/co [Complications]
Electrocardiography
Female
Humans
MedStar Washington Hospital Center
Medicine/Internal Medicine
Journal Article
Masson, Ravi
Bakhshi H, Haddad TM, Masson R
https://dx.doi.org/10.1136/bcr-2020-236009
https://dx.doi.org/10.1136/bcr-2020-236009
ART
Article
0
0
0
0
Article
authcat
authcat
2020-09-02
0
32723779
32723779
2020-09-02
2020-09-02
ART
5487
5487