TY  - BOOK
AU  - Masson, Ravi
TI  - Intermittent left bundle branch block and acute heart failure in trastuzumab-induced cardiotoxicity
SN  - 1757-790X
PY  - 2020///
KW  - *Antineoplastic Agents, Immunological/ae [Adverse Effects]
KW  - *Bundle-Branch Block/ci [Chemically Induced]
KW  - *Heart Failure, Systolic/ci [Chemically Induced]
KW  - *Trastuzumab/ae [Adverse Effects]
KW  - Aged
KW  - Breast Neoplasms/ch [Chemistry]
KW  - Breast Neoplasms/dt [Drug Therapy]
KW  - Bundle-Branch Block/pp [Physiopathology]
KW  - Cardiotoxicity/co [Complications]
KW  - Electrocardiography
KW  - Female
KW  - Humans
KW  - MedStar Washington Hospital Center
KW  - Medicine/Internal Medicine
KW  - Journal Article
N2  - A 70-year-old woman with HER2+/ER+ breast cancer on adjuvant trastuzumab therapy without a history of cardiovascular disease presented with respiratory failure from influenza and was found to have intermittent left bundle branch block (LBBB) with new onset systolic heart failure. Her course was complicated by polymorphic ventricular tachycardia and recurrent chest pain. Significant investigations included a normal cardiac MRI and cardiac catheterisation with unobstructed coronaries. It was determined that the aetiology of her heart failure was trastuzumab-induced cardiotoxicity after comprehensive workup. This case highlights an uncommon presentation of LBBB and the steps taken to diagnose a rare cardiomyopathy. Copyright (c) BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ
UR  - https://dx.doi.org/10.1136/bcr-2020-236009
ER  -