TY  - BOOK
AU  - Nazari, Matthew
TI  - Pathophysiology and Acute Management of Tachyarrhythmias in Pheochromocytoma: JACC Review Topic of the Week. [Review]
SN  - 0735-1097
PY  - 2020///
KW  - *Patient Care Management/mt [Methods]
KW  - *Pheochromocytoma
KW  - *Tachycardia
KW  - Adrenal Gland Neoplasms/co [Complications]
KW  - Adrenal Gland Neoplasms/me [Metabolism]
KW  - Adrenal Gland Neoplasms/pa [Pathology]
KW  - Humans
KW  - Pheochromocytoma/co [Complications]
KW  - Pheochromocytoma/me [Metabolism]
KW  - Pheochromocytoma/pa [Pathology]
KW  - Tachycardia/et [Etiology]
KW  - Tachycardia/pp [Physiopathology]
KW  - Tachycardia/th [Therapy]
KW  - MedStar Washington Hospital Center
KW  - Medicine/Internal Medicine
KW  - Journal Article
KW  - Review
N2  - Pheochromocytomas, arising from chromaffin cells, produce catecholamines, epinephrine and norepinephrine. The tumor biochemical phenotype is defined by which of these exerts the greatest influence on the cardiovascular system when released into circulation in high amounts. Action on the heart and vasculature can cause potentially lethal arrhythmias, often in the setting of comorbid blood pressure derangements. In a review of electrocardiograms obtained on pheochromocytoma patients (n = 650) treated at our institution over the last decade, severe and refractory sinus tachycardia, atrial fibrillation, and ventricular tachycardia were found to be the most common or life-threatening catecholamine-induced tachyarrhythmias. These arrhythmias, arising from catecholamine excess rather than from a primary electrophysiologic substrate, require special considerations for treatment and complication avoidance. Understanding the synthesis and release of catecholamines, the adrenoceptors catecholamines bind to, and the cardiac and vascular response to epinephrine and norepinephrine underlies optimal management in catecholamine-induced tachyarrhythmias. Copyright (c) 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved
UR  - https://dx.doi.org/10.1016/j.jacc.2020.04.080
ER  -