Decision-Making Analysis for Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer: A Survey by the Executive Committee of the Peritoneal Surface Oncology Group International (PSOGI). - 2021

DISCUSSION AND CONCLUSION: Among surgical oncology experts in peritoneal surface malignancy and HIPEC, HIPEC plays an important role in primary and recurrent ovarian cancer, and the PCI is the most important criterion in this decision. Copyright (c) 2020 S. Karger AG, Basel. METHODS: The members of the executive committee of the Peritoneal Surface Oncology Group International (PSOGI) were asked to describe the clinical conditions under which they would recommend HIPEC in patients with ovarian cancer and to describe any disease or patient characteristics relevant to their decision. All answers were then merged and converted into decision trees. The decision trees were then analyzed by applying the objective consensus methodology. OBJECTIVES: To assess the individual treatment strategies among international experts in peritoneal carcinosis, specifically their decision-making in the process of patient selection for hyperthermic intraperitoneal chemotherapy (HIPEC) in women suffering from ovarian cancer, to identify relevant decision-making criteria, and to quantify the level of consensus for or against HIPEC. RESULTS: Nine experts in surgical oncology provided information on their multidisciplinary treatment strategy including HIPEC for patients with advanced ovarian cancer. Three of the total of 12 experts did not perform HIPEC. Five criteria relevant to the decision on whether HIPEC is performed were applied. In patients with resectable disease, a peritoneal cancer index (PCI) <21, and epithelial ovarian cancer without distant metastasis, consent was received by 75% to perform HIPEC for women suffering from recurrent disease. Furthermore, in the primary disease setting, consent was received by 67% to perform HIPEC according to the same criteria.


English

0030-2414

000510098 [pii] 10.1159/000510098 [doi]


*Clinical Decision-Making
*Hyperthermic Intraperitoneal Chemotherapy
*Ovarian Neoplasms/dt [Drug Therapy]
*Peritoneal Neoplasms/dt [Drug Therapy]
Adult
Aged
Combined Modality Therapy
Cytoreduction Surgical Procedures/mt [Methods]
Female
Humans
Middle Aged
Neoplasm Recurrence, Local/dt [Drug Therapy]
Neoplasm Recurrence, Local/pa [Pathology]
Neoplasm Recurrence, Local/su [Surgery]
Ovarian Neoplasms/ep [Epidemiology]
Ovarian Neoplasms/pa [Pathology]
Ovarian Neoplasms/su [Surgery]
Peritoneal Neoplasms/ep [Epidemiology]
Peritoneal Neoplasms/pa [Pathology]
Treatment Outcome


Washington Cancer Institute


Journal Article