TY  - BOOK
AU  - Adhikari, Tripti
AU  - Al-Shbool, Ghassan
AU  - Baez-Sosa, Valentina
AU  - Desai, Sanjal
AU  - Fernandez, Stephen J
AU  - Fishbein, Dawn
AU  - Hameed, Rumaisa
AU  - Malkovska, Vera
AU  - Paku, Emily
AU  - Stingo, Facundo
AU  - Vakiti, Anusha
TI  - Clearance of Hepatitis C Virus (HCV) Is Associated With Improved Outcomes in HCV-Associated Lymphoma
SN  - 2152-2669
PY  - 2021///
KW  - *Antiviral Agents/tu [Therapeutic Use]
KW  - *Hepacivirus/ip [Isolation & Purification]
KW  - *Hepatitis C/dt [Drug Therapy]
KW  - *Lymphoma, Non-Hodgkin/mo [Mortality]
KW  - Adolescent
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Female
KW  - Hepacivirus/ge [Genetics]
KW  - Hepatitis C/vi [Virology]
KW  - Humans
KW  - Lymphoma, Non-Hodgkin/th [Therapy]
KW  - Lymphoma, Non-Hodgkin/vi [Virology]
KW  - Male
KW  - Middle Aged
KW  - Progression-Free Survival
KW  - Retrospective Studies
KW  - RNA, Viral/ip [Isolation & Purification]
KW  - Young Adult
KW  - MedStar Health Research Institute
KW  - MedStar Heart & Vascular Institute
KW  - MedStar Washington Hospital Center
KW  - Washington Cancer Institute
KW  - Washington Cancer Institute H
KW  - Medicine/Infectious Diseases
KW  - Medicine/Internal Medicine
KW  - Journal Article
N2  - BACKGROUND: Improved hepatitis C virus (HCV) clearance due to directly acting antiviral agents has led to remarkably improved outcomes of indolent HCV-associated non-Hodgkin lymphoma (NHL). The impact of directly acting antivirals on the outcomes of aggressive NHL is still under investigation. Characteristics of HCV-associated NHL in black patients are not well characterized. We report outcomes of HCV-associated NHL compared to their HCV-negative counterparts in a predominantly black population; CONCLUSION: HCV clearance is positively associated with lymphoma outcomes in black patients. Patients who clear HCV have noninferior outcomes to HCV- patients, while those who fail to clear HCV have significantly worse outcomes. Copyright (c) 2020 Elsevier Inc. All rights reserved; PATIENTS AND METHODS: Patients with lymphoma between January 2007 and December 2017 were retrospectively studied. Depending on presence or absence of HCV RNA, patients were grouped into HCV positive (HCV+) and HCV negative (HCV-) cohorts. Depending on virologic clearance (VC), HCV+ were classified into HCV+ with VC and HCV+ without VC. Overall response rate (ORR), complete response, overall survival (OS), and progression-free survival (PFS) of HCV+ patients with and without VC were compared to HCV- patients; RESULTS: Of 397 patients with lymphoma, 40 had HCV. Black comprised 90% of HCV+ patients. Diffuse large B-cell lymphoma was most frequent (47%) in the HCV+ group. HCV+ patients without VC had significantly worse OS and PFS compared to HCV- patients. There were no differences in ORR, complete response, PFS, and OS of HCV+ patients with VC and HCV- patients. These results were consistent in subgroups of diffuse large B-cell lymphoma and aggressive lymphoma
UR  - https://dx.doi.org/10.1016/j.clml.2020.09.011
ER  -