TY  - BOOK
AU  - Alkhalil, Abdulnaser
AU  - Ball, Robert
AU  - Carney, Bonnie C
AU  - Garg, Gaurav
AU  - Moffatt, Lauren T
AU  - Shupp, Jeffrey W
TI  - Cutaneous Thermal Injury Modulates Blood and Skin Metabolomes Differently in a Murine Model
SN  - 1559-047X
PY  - 2021///
KW  - *Biomarkers/me [Metabolism]
KW  - *Burns/me [Metabolism]
KW  - *Hot Temperature
KW  - *Metabolome
KW  - Animals
KW  - Burns/pa [Pathology]
KW  - Disease Models, Animal
KW  - Metabolomics/mt [Methods]
KW  - Mice
KW  - MedStar Health Research Institute
KW  - MedStar Washington Hospital Center
KW  - Firefighters' Burn and Surgical Research Laboratory
KW  - Surgery/Burn Services
KW  - Journal Article
N1  - Available online through MWHC library: 2006 - present, Available in print through MWHC library: 2006 - present
N2  - As the field of metabolomics develops further, investigations of how the metabolome is affected following thermal injury may be helpful to inform diagnostics and guide treatments. In this study changes to the metabolome were tested and validated in a murine burn injury model. After a 30% total body surface scald injury or sham procedure sera and skin biopsies were collected at 1, 2, 6, or 24 hours. Burn-specific changes in the metabolome were detected compared to sham animals. The sera metabolome exhibited a more rapid response to burn injury than that of the skin and it peaked more proximal to injury (6 vs 24 hours). Progression of metabolic response in the skin was less synchronous and showed a higher overlap of the significantly modified metabolites (SMMs) among tested time-points. Top affected pathways identified by SMMs of skin included inositol phosphate metabolism, ascorbate and alderate metabolism, caffeine metabolism, and the pentose phosphate pathway. Future research is warranted in human and larger animal models to further elucidate the role of metabolomic perturbations and the pathophysiology following burn injury. Copyright (c) The Author(s) 2020. Published by Oxford University Press on behalf of the American Burn Association
UR  - https://dx.doi.org/10.1093/jbcr/iraa209
ER  -