TY  - BOOK
AU  - Nowak-Choi, Kamila
TI  - Resected WHO grade I meningioma and predictors of local control
SN  - 0167-594X
PY  - 2021///
KW  - *Meningeal Neoplasms/pa [Pathology]
KW  - *Meningioma/pa [Pathology]
KW  - *Mitotic Index
KW  - *Neoplasm Recurrence, Local/pa [Pathology]
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Biomarkers, Tumor/an [Analysis]
KW  - Female
KW  - Humans
KW  - Ki-67 Antigen/an [Analysis]
KW  - Male
KW  - Meningeal Neoplasms/su [Surgery]
KW  - Meningioma/su [Surgery]
KW  - Middle Aged
KW  - Neoplasm Grading
KW  - Retrospective Studies
KW  - World Health Organization
KW  - MedStar Franklin Square Medical Center
KW  - Journal Article
N1  - Available online from MWHC library: 1997 - present
N2  - CONCLUSIONS: WHO grade 1 meningiomas exhibit a significant rate of recurrence following resection. While Ki-67 is not part of the WHO grading criteria of meningiomas, a value greater than 5% is an independent predictor for increased risk of local recurrence following surgical resection; INTRODUCTION: Despite optimal surgical resection, meningiomas may recur, with increasing grade and the degree of resection being predictive of risk. We hypothesize that an increasing Ki67 correlates with a higher risk of recurrence of resected WHO grade I meningiomas; METHODS: The study population consisted of patients with resected WHO grade 1 meningiomas in locations outside of the base of skull. Digitally scanned slides stained for Ki67 were analyzed using automatic image analysis software in a standardized fashion; RESULTS: Recurrence was observed in 53 (17.7%) of cases with a median follow up time of 25.8 months. Ki67 ranged from 0 to 30%. Median Ki67 was 5.1% for patients with recurrence and 3.5% for patients without recurrence. In unadjusted analyses, high Ki-67 (>= 5 vs. < 5) vs. >= 5) was associated with over a twofold increased risk of recurrence (13.1% vs. 27% respectively; HR 2.1731; 95% CI [1.2534, 3.764]; p = 0.006). After Adjusting for patient or tumor characteristics, elevated Ki-67 remained significantly correlated with recurrence. Grade 4 Simpson resection was noted in 71 (23.7%) of patients and it was associated with a significantly increased risk of recurrence (HR 2.56; 95% CI [1.41, 4.6364]; p = 0.002)
UR  - https://dx.doi.org/10.1007/s11060-020-03688-1
ER  -