TY - BOOK AU - Gaur Khaitan, Puja TI - Gastric cancer in Jammu and Kashmir, India: A review of genetic perspectives. [Review] SN - 1998-4138 PY - 2020/// KW - IN PROCESS -- NOT YET INDEXED KW - MedStar Washington Hospital Center KW - Surgery/Thoracic Surgery KW - Journal Article KW - Review N2 - Gastric Carcinoma (GC) is one of the most common malignancies, which accounts for 6.8% of total cancer population worldwide. In India, the northeastern region has the highest gastric cancer incidence, and the Kashmir Valley has a very high incidence of gastric cancer as compared to other parts of Northern India. It exceeds 40% of total cancers with an incidence rate of 3-6-fold higher than other metro cities of India. Gastric cancer is a heterogeneous disease where most of the cases are sporadic, and <15% are due to obvious familial clustering. The heterogeneous nature of the disease can be associated with differences in genetic makeup of an individual. A better understanding of genetic predisposition toward GC will be helpful in promoting personalized medicine. The aim of this review is to analyze the development and progression of GC and to explore the genetic perspectives of the disease with special emphasis on Jammu and Kashmir, India UR - https://dx.doi.org/10.4103/jcrt.JCRT_12_19 ER -