02637nam a22005177a 4500
210401s20202020 xxu||||| |||| 00| 0 eng d
0967-5868
10.1016/j.jocn.2020.08.026 [doi]
PMC7434499 [pmc]
S0967-5868(20)31467-3 [pii]
Ovid MEDLINE(R)
33222915
Intracranial hemorrhage in critically ill patients hospitalized for COVID-19.
Journal of Clinical Neuroscience. 81:192-195, 2020 Nov.
J Clin Neurosci. 81:192-195, 2020 Nov.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2020
FY2021
ppublish
2021-04-01
In this study, we report three cases of spontaneous intracranial hemorrhage in patients who were initially hospitalized at our tertiary care center in Washington, DC with symptoms of COVID-19. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was diagnosed in all three patients, who were critically ill, requiring intubation and ventilatory support. During their protracted hospitalizations, subsequent imaging disclosed intracranial hemorrhages, including intracerebral and subarachnoid hemorrhages, in the context of anticoagulation and coagulopathy. We believe this is related to the tropism of SARS-CoV-2 to the endothelial lining of the cerebral vasculature via their angiotensin-converting enzyme (ACE) II receptors. Given our findings, we advocate heightened vigilance for intracerebral hemorrhage events, and scanning when practicable, in COVID-19 patients which have prolonged ventilatory support and depressed neurologic examinations. Copyright (c) 2020. Published by Elsevier Ltd.
English
*Cerebral Hemorrhage/vi [Virology]
*COVID-19/co [Complications]
Aged
Critical Illness
Female
Hospitalization
Humans
Male
Middle Aged
SARS-CoV-2
MedStar Washington Hospital Center
Neurosurgery
Surgical Critical Care
Case Reports
Journal Article
Chang, Jason
Conte, Anthony G
Fayed, Islam
Mai, Jeffrey C
Pivazyan, Gnel
Chang J, Conte AG, Fayed I, Mai JC, Pivazyan G
https://dx.doi.org/10.1016/j.jocn.2020.08.026
https://dx.doi.org/10.1016/j.jocn.2020.08.026
ART
Article
0
0
0
0
Article
authcat
authcat
2021-04-01
0
33222915
33222915
2021-04-01
2021-04-01
ART
6256
6256