TY  - BOOK
AU  - Chang, Jason
AU  - Conte, Anthony G
AU  - Fayed, Islam
AU  - Mai, Jeffrey C
AU  - Pivazyan, Gnel
TI  - Intracranial hemorrhage in critically ill patients hospitalized for COVID-19
SN  - 0967-5868
PY  - 2020///
KW  - *Cerebral Hemorrhage/vi [Virology]
KW  - *COVID-19/co [Complications]
KW  - Aged
KW  - Critical Illness
KW  - Female
KW  - Hospitalization
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - SARS-CoV-2
KW  - MedStar Washington Hospital Center
KW  - Neurosurgery
KW  - Surgical Critical Care
KW  - Case Reports
KW  - Journal Article
N2  - In this study, we report three cases of spontaneous intracranial hemorrhage in patients who were initially hospitalized at our tertiary care center in Washington, DC with symptoms of COVID-19. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was diagnosed in all three patients, who were critically ill, requiring intubation and ventilatory support. During their protracted hospitalizations, subsequent imaging disclosed intracranial hemorrhages, including intracerebral and subarachnoid hemorrhages, in the context of anticoagulation and coagulopathy. We believe this is related to the tropism of SARS-CoV-2 to the endothelial lining of the cerebral vasculature via their angiotensin-converting enzyme (ACE) II receptors. Given our findings, we advocate heightened vigilance for intracerebral hemorrhage events, and scanning when practicable, in COVID-19 patients which have prolonged ventilatory support and depressed neurologic examinations. Copyright (c) 2020. Published by Elsevier Ltd
UR  - https://dx.doi.org/10.1016/j.jocn.2020.08.026
ER  -