02976nam a22004577a 4500
210607s20212021 xxu||||| |||| 00| 0 eng d
1058-2916
00002480-900000000-98280 [pii]
10.1097/MAT.0000000000001378 [doi]
Ovid MEDLINE(R)
33927085
The Impact of Adverse Events on Functional Capacity and Quality of Life After HeartWare Ventricular Assist Device Implantation.
ASAIO Journal. 67(10):1159-1162, 2021 10 01.
ASAIO J. 67(10):1159-1162, 2021 10 01.
ASAIO J. 2021 Apr 21
ASAIO journal (American Society for Artificial Internal Organs : 1992)
2021
FY2022
aheadofprint
ppublish
2021-06-07
ASAIO Journal. 2021 Apr 21
FY2021
Left ventricular assist devices (LVADs) improve quality of life (QoL) and functional capacity (FC) for patients with advanced heart failure. The association between adverse events (AEs) and changes in QoL and FC are unknown. Patients treated with the HeartWare ventricular assist device (HVAD) with paired 6-minute walk distance (6MWD, n = 263) and Kansas City Cardiomyopathy Questionnaires (KCCQ, n = 272) at baseline and 24 months in the ENDURANCE and ENDURANCE Supplemental Trial databases were included. Patients were stratified based upon occurrence of clinically significant AEs during the first 24 months of support and analyzed for the mean change in 6MWD and KCCQ. The impact of AE frequency on change in 6MWD and KCCQ from baseline to 24 months was evaluated. Of the AEs examined, only sepsis was associated with an improvement in 6MWD (109 m vs. 16 m, p = 0.002). Patients without improvement in 6MWD test from baseline to 24 months had significantly more AEs than those with FC improvement (p = 0.0002). Adverse events did not affect the KCCQ overall summary score. In this analysis, patients with fewer AEs had greater improvement in FC during the 24-month follow up. The frequency of AEs did not have a significant impact on QoL after LVAD implantation. Copyright (c) 2021 by the American Society for Artificial Internal Organs.
English
*Heart Failure
*Heart-Assist Devices
Heart Failure/su [Surgery]
Heart-Assist Devices/ae [Adverse Effects]
Humans
Quality of Life
Treatment Outcome
Walking
MedStar Heart & Vascular Institute
Journal Article
Boyce, Steven W
Najjar, Samer S
Aaronson KD, Birks E, Boyce S, Itoh A, Milano CA, Mokadam N, Najjar SS, Pagani FD, Pamboukian S, Reid B, Rogers JG, Samsky MD, Slaughter MS
https://dx.doi.org/10.1097/MAT.0000000000001378
https://dx.doi.org/10.1097/MAT.0000000000001378
ART
Article
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0
0
0
Article
authcat
authcat
2021-06-07
0
33927085
33927085
2021-06-07
2021-06-07
ART
6264
6264