TY  - BOOK
AU  - Howard, Barbara V
AU  - Umans, Jason G
TI  - Plasma epoxyeicosatrienoic acids and dihydroxyeicosatrieonic acids, insulin, glucose and risk of diabetes: The strong heart study
SN  - 2352-3964
PY  - 2021///
KW  - *8,11,14-Eicosatrienoic Acid/bl [Blood]
KW  - *Biomarkers/bl [Blood]
KW  - *Blood Glucose
KW  - *Diabetes Mellitus, Type 2/et [Etiology]
KW  - *Diabetes Mellitus, Type 2/me [Metabolism]
KW  - *Insulin/bl [Blood]
KW  - 8,11,14-Eicosatrienoic Acid/aa [Analogs & Derivatives]
KW  - Adolescent
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Case-Control Studies
KW  - Cross-Sectional Studies
KW  - Diabetes Mellitus, Type 2/bl [Blood]
KW  - Diabetes Mellitus, Type 2/ep [Epidemiology]
KW  - Disease Susceptibility
KW  - Female
KW  - Glucose/me [Metabolism]
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Risk Assessment
KW  - Risk Factors
KW  - Young Adult
KW  - MedStar Health Research Institute
KW  - Journal Article
N2  - BACKGROUND: Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid with multiple biological functions. Rodent experiments suggest EETs play a role in insulin sensitivity and diabetes, but evidence in humans is limited. To address this knowledge gap, we conducted a case-cohort study in the Strong Heart Family Study, a prospective cohort among American Indians; FINDINGS: We observed no significant association of total EET or DHET levels with incident diabetes. In addition, plasma EETs were not associated with plasma insulin or plasma glucose. However, higher plasma 14,15-DHET was associated with lower plasma insulin and lower plasma glucose; FUNDING: US National Institutes of Health. Copyright (c) 2021 The Authors. Published by Elsevier B.V. All rights reserved; INTERPRETATION: In this first prospective study of EETs and diabetes, we found no evidence for a role of total plasma EETs in diabetes. The novel associations of 14,15-DHET with insulin and glucose warrant replication and exploration of possible mechanisms; METHODS: We measured 4 EET species and 4 species of corresponding downstream metabolites, dihydroxyeicosatrieonic acids (DHETs), in plasma samples from 1161 participants, including 310 with type 2 diabetes. We estimated the associations of total (esterified and free) EETs and DHETs with incident diabetes risk, adjusting for known risk factors. We also examined cross-sectional associations with plasma fasting insulin and glucose in the case-cohort and in 271 participants without diabetes from the older Strong Heart Study cohort, and meta-analyzed the results from the 2 cohorts
UR  - https://dx.doi.org/10.1016/j.ebiom.2021.103279
ER  -