TY  - BOOK
AU  - DiSciullo, Alison
AU  - Kawakita, Tetsuya
AU  - Landy, Helain
AU  - Mokhtari, Neggin
TI  - Effect of mild preoperative thrombocytopenia on postpartum hemorrhage after cesarean deliveries
SN  - 2589-9333
PY  - 2021///
KW  - *Postpartum Hemorrhage
KW  - *Thrombocytopenia
KW  - Cesarean Section/ae [Adverse Effects]
KW  - Female
KW  - Gestational Age
KW  - Humans
KW  - Postpartum Hemorrhage/ep [Epidemiology]
KW  - Pregnancy
KW  - Retrospective Studies
KW  - Thrombocytopenia/ep [Epidemiology]
KW  - MedStar Washington Hospital Center
KW  - MedStar Washington Hospital Centeretsuya
KW  - Maternal-Fetal Medicine Fellowship
KW  - Obstetrics & Gynecology Residency
KW  - Obstetrics and Gynecology/Maternal-Fetal Medicine
KW  - Journal Article
N2  - BACKGROUND: Thrombocytopenia at time of delivery is considered to be a risk factor for postpartum hemorrhage. However, platelet count thresholds for postpartum hemorrhage are variable and not extensively studied; CONCLUSION: Preoperative mild thrombocytopenia was not associated with postpartum hemorrhage, red blood cell transfusion, wound complications, or postpartum Emergency Department visits in women undergoing cesarean delivery. Copyright (c) 2021. Published by Elsevier Inc; OBJECTIVE: To examine if mild thrombocytopenia is associated with an increased risk of postpartum hemorrhage among women undergoing cesarean delivery; RESULTS: Of 3,133 women, 2,799 (89.3%) had normal platelet levels, 298 (9.5%) had mild thrombocytopenia, and 36 (1.2%) had moderate to severe thrombocytopenia. There were no differences in the risks of postpartum hemorrhage, need for a red blood cell transfusion, wound complications or postpartum Emergency Department visit comparing women with normal platelet counts to those with mild thrombocytopenia (24.6% vs. 25.8% [aOR 1.16; 95%CI 0.88-1.54]; 6.5% vs 6.7% [aOR 1.34; 95%CI 0.80-2.24]; 4.5% vs. 5.4% [aOR 1.53; 95%CI 0.88-2.64]; 9.0% vs. 10.7% [aOR 1.37; 95%CI 0.92-2.03, respectively); STUDY DESIGN: This was a retrospective cohort study of all women who underwent a cesarean delivery at a tertiary care hospital Labor and Delivery unit from September 2015 to June 2018. Women with normal platelet counts (>=150,000/microL) were compared to women with mild thrombocytopenia (100-149,000/microL). Women were excluded if they had moderate to severe thrombocytopenia (platelet count less than 100,000/microL) or had received a platelet transfusion. The primary outcome was postpartum hemorrhage (quantitative blood loss >=1000 mL). Secondary outcomes included frequencies of red blood cell transfusion, wound complications (surgical site infections, dehiscence, or hematoma), and postpartum Emergency Department visits. Adjusted odds ratios (aOR) with 95% confidence intervals (95%CI) were calculated, controlling for maternal age, gestational age, BMI, scheduled cesarean, hypertension, and pre-operative hemoglobin level
UR  - https://dx.doi.org/10.1016/j.ajogmf.2021.100368
ER  -