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2211-0348
10.1016/j.msard.2021.103011 [doi]
S2211-0348(21)00278-9 [pii]
Ovid MEDLINE(R)
34015641
Conus involvement and leptomeningeal enhancement in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder: A case report.
Multiple Sclerosis and Related Disorders. 52:103011, 2021 May 07.
Mult Scler Relat Disord. 52:103011, 2021 May 07.
Multiple sclerosis and related disorders
2021
FY2021
2021 May 07
aheadofprint
2021-06-28
There are a variety of clinical phenotypes and radiological features that continue to make a diagnosis of neuromyelitis optica spectrum disorder (NMOSD) challenging. We present an atypical case of an adult woman who presented with flaccid paralysis of all extremities with unusual neuroimaging features, including extensive enhancing lesions in the upper cervical cord and conus medullaris with associated leptomeningeal enhancement. She was ultimately found to have AQP4 antibody-positive NMOSD. We discuss the factors that complicated a timely diagnosis, including her atypical radiographic features and an initially negative cell-based assay for myelin oligodendrocyte glycoprotein (MOG) and aquaporin-4 (AQP4) antibodies. Despite the rarity of conus medullaris involvement or leptomeningeal enhancement in AQP4 antibody-positive NMOSD, it is important to maintain a high level of clinical suspicion to avoid diagnostic and therapeutic delays. Though cell-based assays have high sensitivities, testing should be repeated on negative values in these scenarios. Copyright (c) 2021 Elsevier B.V. All rights reserved.
English
IN PROCESS -- NOT YET INDEXED
MedStar Washington Hospital Center
Neurology
Neurology Residency
Letter
Hu, Nancy
Myers, Cory
Safadi, Amy
Hu NN, Myers CJ, Osborne B, Safadi AL
https://dx.doi.org/10.1016/j.msard.2021.103011
https://dx.doi.org/10.1016/j.msard.2021.103011
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2021-06-28
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34015641
34015641
2021-06-28
2021-06-28
ART
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