TY  - BOOK
AU  - Black, Cara K
AU  - Deldar, Romina
AU  - Fan, Kenneth L
TI  - The "Double hit": Free tissue transfer is optimal in comorbid population with irradiated wounds for successful limb salvage
SN  - 1748-6815
PY  - 2021///
KW  - IN PROCESS -- NOT YET INDEXED
KW  - MedStar Health Research Institute
KW  - MedStar Washington Hospital Center
KW  - MedStar General Surgery Residency
KW  - Surgery/Plastic Surgery
KW  - Journal Article
N1  - Available online from MWHC library: 1995 - present
N2  - BACKGROUND: Radiation therapy causes histopathologic changes in tissues, including fibrosis, loss of tissue planes, and vascular damage, which can lead to chronic wound formation. Patients with nonhealing, irradiated wounds and comorbidities that affect microvasculature suffer a "double hit", which leads to delayed wound healing. Local wound care and grafts are commonly insufficient. In this study, we evaluated limb salvage outcomes and long-term complications after free tissue transfer (FTT) in patients with chronic, irradiated leg wounds; CONCLUSIONS: Radiation therapy in a comorbid population often leads to the formation of chronic nonhealing wounds. We advocate for earlier consideration of FTT to provide healthy vascularized tissues, thereby avoiding prolonged wound care and patient burden. Successful limb salvage outcomes can be achieved. Copyright (c) 2020 Elsevier Ltd. All rights reserved; METHODS: We retrospectively reviewed patients with irradiated lower extremity wounds who underwent FTT from 2012 to 2017. Primary outcomes included limb salvage, ambulation, and overall flap success. Reconstruction involved complete excision of irradiated tissue and coverage with well-vascularized tissue; RESULTS: Seven free flaps in six patients were identified. Average age was 68.4 years and average BMI was 27.8kg/m2. Comorbid conditions included hypertension (57.1%), peripheral vascular disease (57.1%), underlying hypercoagulability (42.9%), diabetes (14.3%), and tobacco use (14.3%). Wounds were present for an average of 25.5 months prior to FTT. Donor sites included anterolateral thigh (71.4%), vastus lateralis (14.3%), and latissimus dorsi (14.3%). Overall flap success rate was 100% with one patient requiring reoperation for dehiscence. Limb salvage rate was 85.7% with one patient undergoing elective amputation due to pain. All patients could ambulate (one used a prosthesis) at a mean follow-up time of 1.4 years
UR  - https://dx.doi.org/10.1016/j.bjps.2020.10.054
ER  -