TY - BOOK AU - Hsia, Amie W AU - Kim, Yongwoo AU - Mehta, Amit TI - Good outcome associated with blood-brain barrier disruption and lower blood pressure after endovascular therapy SN - 1052-3057 PY - 2022/// KW - IN PROCESS -- NOT YET INDEXED KW - MedStar Washington Hospital Center KW - MedStar Georgetown University Hospital/MedStar Washington Hospital Center KW - Neurology KW - Neurology Residency KW - Journal Article N2 - CONCLUSIONS: BBB disruption on 3h post-EVT imaging and lower SBP was associated with favorable outcome. This imaging finding may guide targeted BP therapy and suggests need for a randomized control trial. Copyright Published by Elsevier Inc; METHODS: This is a single-center study of 1) anterior large vessel occlusion stroke patients treated with EVT from 2015 to 2021, 2) achieved mTICI grade 2b or 3. Hyperintense acute reperfusion marker (HARM), hemorrhagic transformation (HT), and midline shift at 3 h post-EVT and 24 h imaging were assessed independently by multiple raters. Binary logistic regression models were used to determine the association of post-EVT SBP with outcomes. BBB disruption was defined as HT or HARM on 3h post-EVT imaging; OBJECTIVES: To evaluate the association between post-endovascular thrombectomy (EVT) blood-brain barrier (BBB) disruption on MRI or CT and average systolic blood pressure (SBP) with favorable 90-day functional outcome. Observational studies have found elevated SBP associated with worse outcomes post-EVT, while recent randomized trials found no difference in targeted BP reduction. There may be a subgroup of patients who benefit from targeted BP reduction post-EVT; RESULTS: Of 103 patients, those with SBP 100-129 versus SBP 130-160 found no significant difference in favorable 90-day outcome (64% vs. 46%, OR 2.11, 95% CI 0.78-5.76, p=0.143). However, among 71 patients with BBB disruption, a significant difference in favorable outcome of 64% in SBP 100-129 vs. 39% in SBP 130-160 group (OR 5.93, 95% CI 1.50-23.45, p=0.011) was found. There was no difference in symptomatic ICH, 90-day mortality, midline shift (>=5 mm), and hemicraniectomy, between BP or BBB groups UR - https://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2022.106870 ER -