TY  - BOOK
AU  - Abramowitz, Jonathan
AU  - Ben-Dor, Itsik
AU  - Case, Brian
AU  - Chezar-Azerrad, Chava
AU  - Forrestal, Brian
AU  - Hashim, Hayder
AU  - Medranda, Giorgio
AU  - Rappaport, Hank
AU  - Rogers, Toby
AU  - Satler, Lowell F
AU  - Shea, Corey
AU  - Waksman, Ron
AU  - Weintraub, William S
AU  - Yerasi, Charan
AU  - Zhang, Cheng
TI  - Comparison of Outcomes in Patients With COVID-19 and Thrombosis Versus Those Without Thrombosis
SN  - 0002-9149
PY  - 2021///
KW  - *Coronary Thrombosis/pp [Physiopathology]
KW  - *COVID-19/pp [Physiopathology]
KW  - *Hospital Mortality
KW  - *Myocardial Infarction/pp [Physiopathology]
KW  - *Pulmonary Embolism/pp [Physiopathology]
KW  - *Stroke/pp [Physiopathology]
KW  - *Venous Thrombosis/pp [Physiopathology]
KW  - Aged
KW  - Aged, 80 and over
KW  - Coronary Thrombosis/co [Complications]
KW  - COVID-19/co [Complications]
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Myocardial Infarction/co [Complications]
KW  - Pulmonary Embolism/co [Complications]
KW  - SARS-CoV-2
KW  - Stroke/co [Complications]
KW  - Venous Thrombosis/co [Complications]
KW  - MedStar Heart & Vascular Institute
KW  - MedStar Washington Hospital Center
KW  - Advanced Cardiac Catheterization Research Fellowship
KW  - Interventional Cardiology Fellowship
KW  - Journal Article
N2  - The occurrence of venous thromboembolisms in patients with COVID-19 has been established. We sought to evaluate the clinical impact of thrombosis in patients with COVID-19 over the span of the pandemic to date. We analyzed patients with COVID-19 with a diagnosis of thrombosis who presented to the MedStar Health system (11 hospitals in Washington, District of Columbia, and Maryland) during the pandemic (March 1, 2020, to March 31, 2021). We compared the clinical course and outcomes based on the presence or absence of thrombosis and then, specifically, the presence of cardiac thrombosis. The cohort included 11,537 patients who were admitted for COVID-19. Of these patients, 1,248 had noncardiac thrombotic events and 1,009 had cardiac thrombosis (myocardial infarction) during their hospital admission. Of the noncardiac thrombotic events, 562 (45.0%) were pulmonary embolisms, 480 (38.5%) were deep venous thromboembolisms, and 347 (27.8%) were strokes. In the thrombosis arm, the mean age of the cohort was 64.5 +/- 15.3 years, 53.3% were men, and the majority were African-American (64.9%). Patients with thrombosis tended to be older with more co-morbidities. The in-hospital mortality rate was significantly higher (16.0%) in patients with COVID-19 with concomitant non-cardiac thrombosis than in those without thrombosis (7.9%, p <0.001) but lower than in patients with COVID-19 with cardiac thrombosis (24.7%, p <0.001). In conclusion, patients with COVID-19 with thrombosis, especially cardiac thrombosis, are at higher risk for in-hospital mortality. However, this prognosis is not as grim as for patients with COVID-19 and cardiac thrombosis. Efforts should be focused on early recognition, evaluation, and intensifying antithrombotic management for these patients. Copyright (c) 2021. Published by Elsevier Inc
UR  - https://dx.doi.org/10.1016/j.amjcard.2021.08.038
ER  -