Perfusion Deficits and Association with Clinical Outcome in Patients with Anterior Choroidal Artery Stroke.

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Citation: Journal of Stroke & Cerebrovascular Diseases. 26(8):1755-1759, 2017 AugPMID: 28457620Institution: MedStar Washington Hospital CenterDepartment: NeurologyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Cerebrovascular Circulation | *Choroid Plexus/bs [Blood Supply] | *Stroke/pp [Physiopathology] | Aged | Aged, 80 and over | Diffusion Magnetic Resonance Imaging | Disability Evaluation | District of Columbia | Female | Humans | Male | Maryland | Middle Aged | Patient Discharge | Perfusion Imaging/mt [Methods] | Recovery of Function | Risk Factors | Stroke/dg [Diagnostic Imaging] | Stroke/th [Therapy] | Thrombolytic Therapy | Treatment OutcomeYear: 2017ISSN:
  • 1052-3057
Name of journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke AssociationAbstract: BACKGROUND AND PURPOSE: Anterior choroidal artery (AChA) strokes have a varied pattern of tissue injury, prognosis, and clinical outcome. It is unclear whether perfusion deficit in AChA stroke is associated with the clinical outcome. This study aims to determine the frequency of perfusion abnormalities in AChA stroke and association with clinical outcome.CONCLUSIONS: Two thirds of patients with an AChA stroke have a perfusion deficit on MRI, higher admission NIHSS, and larger DWI lesion size at presentation.Copyright � 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.METHODS: The study cohort was derived from ischemic stroke patients admitted to 2 stroke centers between July 2001 and July 2014. All patients received an acute magnetic resonance imaging (MRI) scan. Patients with ischemic stroke restricted to the AChA territory were included in the study. Lesion size was measured as the largest diameter on diffusion-weighted imaging (DWI) or apparent diffusion coefficient and divided into 2 groups (<20mm or>20mm). Group comparisons were performed among patients with and without perfusion abnormalities and based on diffusion diameter. Favorable clinical outcome was defined as discharge to home.RESULTS: A total of 120 patients were included in the study. Perfusion deficits were identified in 67% of patients. The admission National Institutes of Health Stroke Scale (NIHSS) was higher in patients with perfusion abnormalities (P=.027). Diameter lesion size on DWI was larger among patients with a perfusion deficit median [interquartile range], 1.63 [1.3-2.0], as compared with those without, 1.18 [1.0-1.7], P<.0001. Patients with a perfusion deficit were less likely to be discharged to home than those without (36% versus 60%, P=.013).All authors: Alqahtani SA, Benson RT, Hsia AW, Leigh R, Luby M, Lynch JK, Nadareishvili ZFiscal year: FY2017Digital Object Identifier: Date added to catalog: 2017-05-08
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Journal Article MedStar Authors Catalog Article 28457620 Available 28457620

BACKGROUND AND PURPOSE: Anterior choroidal artery (AChA) strokes have a varied pattern of tissue injury, prognosis, and clinical outcome. It is unclear whether perfusion deficit in AChA stroke is associated with the clinical outcome. This study aims to determine the frequency of perfusion abnormalities in AChA stroke and association with clinical outcome.

CONCLUSIONS: Two thirds of patients with an AChA stroke have a perfusion deficit on MRI, higher admission NIHSS, and larger DWI lesion size at presentation.

Copyright � 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.

METHODS: The study cohort was derived from ischemic stroke patients admitted to 2 stroke centers between July 2001 and July 2014. All patients received an acute magnetic resonance imaging (MRI) scan. Patients with ischemic stroke restricted to the AChA territory were included in the study. Lesion size was measured as the largest diameter on diffusion-weighted imaging (DWI) or apparent diffusion coefficient and divided into 2 groups (<20mm or>20mm). Group comparisons were performed among patients with and without perfusion abnormalities and based on diffusion diameter. Favorable clinical outcome was defined as discharge to home.

RESULTS: A total of 120 patients were included in the study. Perfusion deficits were identified in 67% of patients. The admission National Institutes of Health Stroke Scale (NIHSS) was higher in patients with perfusion abnormalities (P=.027). Diameter lesion size on DWI was larger among patients with a perfusion deficit median [interquartile range], 1.63 [1.3-2.0], as compared with those without, 1.18 [1.0-1.7], P<.0001. Patients with a perfusion deficit were less likely to be discharged to home than those without (36% versus 60%, P=.013).

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