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Intraperitoneal doxorubicin achieves access to mesenteric lymph nodes, case series of two patients.

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Citation: International Journal of Surgery Case Reports. 54:108-112, 2018 Dec 12.PMID: 30599303Institution: Washington Cancer InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2018 ISSN:

2210-2612

Name of journal: International journal of surgery case reportsAbstract: BACKGROUND: Intraperitoneal chemotherapy has been used extensively to treat cancers that metastasize to the peritoneal surfaces. In the operating room the intraperitoneal chemotherapy is administered with moderate heat. The chemotherapy is used after surgery when there is minimal residual disease. Alternatively, intraperitoneal chemotherapy can be used long-term in an attempt to prevent the progression of disease in patients at high risk for peritoneal metastases to occur during follow-up.CONCLUSION: Doxorubicin chemotherapy was not only present in peritoneal surface tissue but also a surprisingly high level was present in mesenteric lymph nodes in patients treated by HIPEC. This observation may have implications for interpreting clinical future studies performed with HIPEC. To our knowledge, this is the first time this pharmacologic information regarding intraperitoneal chemotherapy access to mesenteric lymph nodes has been reported.Copyright (c) 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.METHODS: Hyperthermic intraperitoneal chemotherapy (HIPEC) with doxorubicin was used to treat peritoneal metastases in two patients. These two patients required generous sampling of mesenteric lymph nodes because involvement of these lymph nodes was suspected on preoperative radiologic studies by computed tomography (CT). The lymph nodes, peritoneal fluid and plasma along with tumor tissue in one patient were subjected to a determination of doxorubicin chemotherapy concentrations by high pressure liquid chromatography (HPLC).RESULTS: The ratio of doxorubicin present in peritoneal fluid as compared to plasma was 80 in patient 1 and 50 in patient 2. There was an increased doxorubicin concentration within lymph nodes as compared to plasma. The accumulation of doxorubicin in lymph nodal tissue was 40 times that of plasma in patient 1 and 30 times that in patient 2. In patient 2, the concentration of doxorubicin in lymph nodes was very similar to the concentration of chemotherapy within tumor nodules.All authors: Stuart OA, Sugarbaker PHFiscal year: FY2019Digital Object Identifier:

https://dx.doi.org/10.1016/j.ijscr.2018.11.065

Date added to catalog: 2019-01-18

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Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	30599303	Available		30599303

BACKGROUND: Intraperitoneal chemotherapy has been used extensively to treat cancers that metastasize to the peritoneal surfaces. In the operating room the intraperitoneal chemotherapy is administered with moderate heat. The chemotherapy is used after surgery when there is minimal residual disease. Alternatively, intraperitoneal chemotherapy can be used long-term in an attempt to prevent the progression of disease in patients at high risk for peritoneal metastases to occur during follow-up.

CONCLUSION: Doxorubicin chemotherapy was not only present in peritoneal surface tissue but also a surprisingly high level was present in mesenteric lymph nodes in patients treated by HIPEC. This observation may have implications for interpreting clinical future studies performed with HIPEC. To our knowledge, this is the first time this pharmacologic information regarding intraperitoneal chemotherapy access to mesenteric lymph nodes has been reported.

METHODS: Hyperthermic intraperitoneal chemotherapy (HIPEC) with doxorubicin was used to treat peritoneal metastases in two patients. These two patients required generous sampling of mesenteric lymph nodes because involvement of these lymph nodes was suspected on preoperative radiologic studies by computed tomography (CT). The lymph nodes, peritoneal fluid and plasma along with tumor tissue in one patient were subjected to a determination of doxorubicin chemotherapy concentrations by high pressure liquid chromatography (HPLC).

RESULTS: The ratio of doxorubicin present in peritoneal fluid as compared to plasma was 80 in patient 1 and 50 in patient 2. There was an increased doxorubicin concentration within lymph nodes as compared to plasma. The accumulation of doxorubicin in lymph nodal tissue was 40 times that of plasma in patient 1 and 30 times that in patient 2. In patient 2, the concentration of doxorubicin in lymph nodes was very similar to the concentration of chemotherapy within tumor nodules.

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