Sodium-glucose cotransporter 2 inhibitors combined with dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes: a review of current clinical evidence and rationale. [Review]
Citation: Drug design, development & therapy. 11:923-937, 2017PMID: 28356718Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Diabetes Mellitus, Type 2/dt [Drug Therapy] | *Dipeptidyl-Peptidase IV Inhibitors/tu [Therapeutic Use] | *Hypoglycemic Agents/tu [Therapeutic Use] | *Sodium-Glucose Transporter 2/ai [Antagonists & Inhibitors] | Dipeptidyl-Peptidase IV Inhibitors/pd [Pharmacology] | Humans | Hypoglycemic Agents/pd [Pharmacology] | Sodium-Glucose Transporter 2/me [Metabolism]Year: 2017ISSN:- 1177-8881
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 28356718 | Available | 28356718 |
Type 2 diabetes mellitus (T2DM) is a progressive and multifactorial cardiometabolic disorder. Almost half of adults with diabetes fail to achieve their recommended glucose control target. This has prompted some clinicians to advocate the use of more intensive initial therapy, including the use of combination therapy to target multiple physiologic defects in diabetes with the goal of achieving and sustaining glucose control. Numerous options exist for combining the various classes of glucose-lowering agents in the treatment of T2DM. This report reviews the mechanism, rationale, and evidence from clinical trials for combining two of the newer drug classes, namely, dipeptidyl peptidase-4 inhibitors and sodium-glucose cotransporter 2 inhibitors, and considers the possible role of such dual therapy in the management of T2DM.
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