Cytoreductive surgery plus hyperthermic perioperative chemotherapy to treat peritoneal metastases from colorectal cancer: standard of care or an experimental approach?.

MedStar author(s):
Citation: Lancet Oncology. 13(8):e362-9, 2012 Aug.PMID: 22846841Institution: MedStar Washington Hospital CenterDepartment: Surgery/General SurgeryForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Antineoplastic Combined Chemotherapy Protocols/st [Standards] | *Carcinoma/sc [Secondary] | *Carcinoma/th [Therapy] | *Colorectal Neoplasms/pa [Pathology] | *Hypothermia, Induced/st [Standards] | *Peritoneal Neoplasms/sc [Secondary] | *Peritoneal Neoplasms/th [Therapy] | *Peritoneum/su [Surgery] | *Standard of Care/st [Standards] | Antineoplastic Combined Chemotherapy Protocols/ae [Adverse Effects] | Carcinoma/mo [Mortality] | Chemotherapy, Adjuvant/st [Standards] | Colorectal Neoplasms/mo [Mortality] | Evidence-Based Medicine/st [Standards] | Humans | Hypothermia, Induced/ae [Adverse Effects] | Patient Selection | Perioperative Care/st [Standards] | Peritoneal Neoplasms/mo [Mortality] | Peritoneum/pa [Pathology] | Practice Guidelines as Topic | Risk Assessment | Risk Factors | Treatment OutcomeYear: 2012Local holdings: Available online from MWHC library: 2001 - presentISSN:
  • 1470-2045
Name of journal: Lancet | The lancet oncologyAbstract: Peritoneal carcinomatosis is a common presentation in patients with metastatic colorectal cancer and the overall survival is poor. In most patients, the disease remains limited to the peritoneal cavity. Therefore, investigators have applied cytoreductive surgery and hyperthermic perioperative chemotherapy as the standard approach for selected patients with peritoneal metastases from colorectal cancer. Overall, very promising long-term survival has been shown in a subset of patients with a limited extent of peritoneal disease before treatment. Whether randomised, controlled trials are needed to definitively show the magnitude of benefit, if any, of this approach is an important question. This Debate outlines the arguments on each side of this issue. Copyright 2012 Elsevier Ltd. All rights reserved.All authors: Ryan DP, Sugarbaker PHFiscal year: FY2013Digital Object Identifier: Date added to catalog: 2013-09-17
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 22846841 Available 22846841

Available online from MWHC library: 2001 - present

Peritoneal carcinomatosis is a common presentation in patients with metastatic colorectal cancer and the overall survival is poor. In most patients, the disease remains limited to the peritoneal cavity. Therefore, investigators have applied cytoreductive surgery and hyperthermic perioperative chemotherapy as the standard approach for selected patients with peritoneal metastases from colorectal cancer. Overall, very promising long-term survival has been shown in a subset of patients with a limited extent of peritoneal disease before treatment. Whether randomised, controlled trials are needed to definitively show the magnitude of benefit, if any, of this approach is an important question. This Debate outlines the arguments on each side of this issue. Copyright 2012 Elsevier Ltd. All rights reserved.

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