Plasma epoxyeicosatrienoic acids and dihydroxyeicosatrieonic acids, insulin, glucose and risk of diabetes: The strong heart study.
Citation: EBioMedicine. 66:103279, 2021 Apr.PMID: 33752126Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *8,11,14-Eicosatrienoic Acid/bl [Blood] | *Biomarkers/bl [Blood] | *Blood Glucose | *Diabetes Mellitus, Type 2/et [Etiology] | *Diabetes Mellitus, Type 2/me [Metabolism] | *Insulin/bl [Blood] | 8,11,14-Eicosatrienoic Acid/aa [Analogs & Derivatives] | Adolescent | Adult | Aged | Aged, 80 and over | Case-Control Studies | Cross-Sectional Studies | Diabetes Mellitus, Type 2/bl [Blood] | Diabetes Mellitus, Type 2/ep [Epidemiology] | Disease Susceptibility | Female | Glucose/me [Metabolism] | Humans | Male | Middle Aged | Risk Assessment | Risk Factors | Young AdultYear: 2021ISSN:- 2352-3964
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 33752126 | Available | 33752126 |
BACKGROUND: Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid with multiple biological functions. Rodent experiments suggest EETs play a role in insulin sensitivity and diabetes, but evidence in humans is limited. To address this knowledge gap, we conducted a case-cohort study in the Strong Heart Family Study, a prospective cohort among American Indians.
FINDINGS: We observed no significant association of total EET or DHET levels with incident diabetes. In addition, plasma EETs were not associated with plasma insulin or plasma glucose. However, higher plasma 14,15-DHET was associated with lower plasma insulin and lower plasma glucose.
FUNDING: US National Institutes of Health. Copyright (c) 2021 The Authors. Published by Elsevier B.V. All rights reserved.
INTERPRETATION: In this first prospective study of EETs and diabetes, we found no evidence for a role of total plasma EETs in diabetes. The novel associations of 14,15-DHET with insulin and glucose warrant replication and exploration of possible mechanisms.
METHODS: We measured 4 EET species and 4 species of corresponding downstream metabolites, dihydroxyeicosatrieonic acids (DHETs), in plasma samples from 1161 participants, including 310 with type 2 diabetes. We estimated the associations of total (esterified and free) EETs and DHETs with incident diabetes risk, adjusting for known risk factors. We also examined cross-sectional associations with plasma fasting insulin and glucose in the case-cohort and in 271 participants without diabetes from the older Strong Heart Study cohort, and meta-analyzed the results from the 2 cohorts.
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