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Thrombotic microangiopathies (TTP, HUS, HELLP). [Review]

MedStar author(s):

Citation: Emergency Medicine Clinics of North America. 32(3):649-71, 2014 Aug.PMID: 25060255Institution: MedStar Washington Hospital CenterDepartment: Emergency MedicineForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Thrombotic Microangiopathies/di [Diagnosis] | Adult | Child | Female | HELLP Syndrome/di [Diagnosis] | HELLP Syndrome/th [Therapy] | Hemolytic-Uremic Syndrome/di [Diagnosis] | Hemolytic-Uremic Syndrome/th [Therapy] | Humans | Immunosuppressive Agents/tu [Therapeutic Use] | Pregnancy | Purpura, Thrombotic Thrombocytopenic/di [Diagnosis] | Purpura, Thrombotic Thrombocytopenic/th [Therapy] | Thrombocytopenia/et [Etiology] | Thrombotic Microangiopathies/et [Etiology] | Thrombotic Microangiopathies/th [Therapy]Local holdings: Available online from MWHC library: 1996 - presentISSN:

0733-8627

Name of journal: Emergency medicine clinics of North AmericaAbstract: Thrombocytopenia, strictly defined as a platelet count less than 150,000, is common in the emergency department. Recognition, diagnostic investigation, and proper disposition of a thrombocytopenic patient are imperative. One group of disorders leading to thrombocytopenia is the thrombotic microangiopathies, hallmarked by platelet destruction. These thrombotic microangiopathies include thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS) and hemolysis, elevated liver enzyme levels, low platelet count (HELLP), which should be distinguished from similar disease processes such as immune thrombocytopenia (ITP), disseminated intravascular coagulation (DIC) and heparin induced thrombocytopenia (HIT). In this article, clinical presentations, pathophysiology, diagnostic workup, management plans, complications, and dispositions are addressed for this complex group of platelet disorders. Copyright 2014 Elsevier Inc. All rights reserved.All authors: Graham A, Kappler S, Ronan-Bentle SDigital Object Identifier:

http://dx.doi.org/10.1016/j.emc.2014.04.008

Date added to catalog: 2014-09-23

Holdings ( 1 )
Title notes ( 3 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article		Available		25060255

Available online from MWHC library: 1996 - present

Thrombocytopenia, strictly defined as a platelet count less than 150,000, is common in the emergency department. Recognition, diagnostic investigation, and proper disposition of a thrombocytopenic patient are imperative. One group of disorders leading to thrombocytopenia is the thrombotic microangiopathies, hallmarked by platelet destruction. These thrombotic microangiopathies include thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS) and hemolysis, elevated liver enzyme levels, low platelet count (HELLP), which should be distinguished from similar disease processes such as immune thrombocytopenia (ITP), disseminated intravascular coagulation (DIC) and heparin induced thrombocytopenia (HIT). In this article, clinical presentations, pathophysiology, diagnostic workup, management plans, complications, and dispositions are addressed for this complex group of platelet disorders. Copyright 2014 Elsevier Inc. All rights reserved.

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