Diagnostic and prognostic performances of serum procalcitonin in patients with bloodstream infections: A parallel, case-control study comprising adults and elderly.
Citation: Revista Da Associacao Medica Brasileira. 63(6):521-526, 2017 JunPMID: 28876428Institution: Medstar Harbor HospitalDepartment: Internal MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Calcitonin/bl [Blood] | *Sepsis/bl [Blood] | *Sepsis/di [Diagnosis] | Adult | Aged | Bacteremia/bl [Blood] | Biomarkers/bl [Blood] | Case-Control Studies | Enzyme-Linked Immunosorbent Assay | Female | Humans | Male | Middle Aged | Prognosis | Prospective Studies | Sensitivity and SpecificityYear: 2017ISSN:- 0104-4230
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 28876428 | Available | 28876428 |
Conclusion:: Although admission serum PCT is a sensitive and specific biomarker for the diagnosis of BSIs in patients younger than 65 years old, its short-term prognostic value is comparable between adults and the elderly.
Method:: A total of 176 patients with culture-proven BSIs and 200 healthy counterparts were studied prospectively. Participants were studied in two adult (age<=65 years, n=92) and elderly (age>65 years, n=84) groups. Admission serum PCT level was measured using a standard enzyme-linked immunosorbent assay (ELISA) technique.
Objective:: To examine the diagnostic and prognostic performances of serum procalcitonin (PCT) in adult and elderly patients with bloodstream infections (BSIs).
Results:: The mean serum PCT level (in ng/mL) was significantly higher in cases than in controls (0.18 vs. 0.07, p=0.01 in adults; 0.20 vs. 0.07, p=0.002 in elderly). At cut-off values of 0.09 ng/mL in adults and 0.08 ng/mL in the elderly, the corresponding sensitivity and specificity were 82.6 and 82.0% in adults, and 69.1 and 70.0% in elderly, respectively. At a cut-off value of 0.2 ng/mL, the sensitivity and specificity of serum PCT in predicting 28-day mortality were 81 and 81.7% in adults, and 75 and 80.4% in elderly, respectively.
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