A tale of autoimmunity: thymoma, thymectomy, and systemic lupus erythematosus. [Review]
Citation: Clinical Rheumatology. 39(7):2227-2234, 2020 Jul.PMID: 32277368Department: MedStar Health Baltimore ResidentsForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Lupus Erythematosus, Systemic/et [Etiology] | *Red-Cell Aplasia, Pure/et [Etiology] | *T-Lymphocytes/im [Immunology] | *Thymus Gland/im [Immunology] | Aged | Autoimmunity | Humans | Lupus Erythematosus, Systemic/im [Immunology] | Male | Radiography | Red-Cell Aplasia, Pure/im [Immunology] | T-Lymphocytes/pa [Pathology] | Thymectomy/ae [Adverse Effects] | Thymoma/pa [Pathology] | Thymoma/su [Surgery] | Thymus Neoplasms/pa [Pathology] | Thymus Neoplasms/su [Surgery] | Tomography, X-Ray ComputedYear: 2020ISSN:- 0770-3198
- Mollaeian, Arash:
- https://orcid.org/0000-0002-1483-2241
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 32277368 | Available | 32277368 |
The thymus plays an integral role in immune system regulation, modulating the development, diversity, and selection of T lymphocytes, a critical feature for the prevention of T cell-mediated autoimmunity. Thymoma is a rare tumor of the thymus. Autoimmune diseases and paraneoplastic syndromes such as myasthenia gravis, pure red blood cell aplasia, and systemic lupus erythematosus, although relatively uncommon, have been described in association with thymomas. Rare cases of post-thymectomy autoimmune related diseases, including systemic lupus erythematosus and pure red cell aplasia, have been reported in the literature. Here, we present the case of a 65-year-old male who developed systemic lupus erythematosus 2 years after thymectomy in the setting of thymoma-associated pure red cell aplasia.
English