Implications of Clostridium septicum in vascular surgery: a case report and outcomes literature review.

MedStar author(s):
Citation: Annals of Vascular Surgery. 43:314.e5-314.e11, 2017 AugPMID: 28479472Institution: MedStar Washington Hospital CenterDepartment: SurgeryForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Adenocarcinoma/mi [Microbiology] | *Aneurysm, Infected/su [Surgery] | *Aortic Aneurysm, Abdominal/su [Surgery] | *Blood Vessel Prosthesis Implantation | *Clostridium Infections/su [Surgery] | *Clostridium septicum/ip [Isolation & Purification] | *Colonic Neoplasms/mi [Microbiology] | Adenocarcinoma/dg [Diagnostic Imaging] | Adenocarcinoma/su [Surgery] | Adult | Aged | Aged, 80 and over | Aneurysm, Infected/dg [Diagnostic Imaging] | Aneurysm, Infected/mi [Microbiology] | Anti-Bacterial Agents/tu [Therapeutic Use] | Aortic Aneurysm, Abdominal/dg [Diagnostic Imaging] | Aortic Aneurysm, Abdominal/mi [Microbiology] | Aortography/mt [Methods] | Biopsy | Clostridium Infections/dg [Diagnostic Imaging] | Clostridium Infections/mi [Microbiology] | Colectomy | Colonic Neoplasms/dg [Diagnostic Imaging] | Colonic Neoplasms/su [Surgery] | Colonoscopy | Computed Tomography Angiography | Early Detection of Cancer/mt [Methods] | Female | Humans | Male | Middle Aged | Treatment OutcomeYear: 2017Local holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007ISSN:
  • 0890-5096
Name of journal: Annals of vascular surgeryAbstract: Clostridium septicum is a rare organism, accounting for approximately 1.3% of clostridial infections and is associated with synchronous colonic malignancy. This case report describes a patient successfully treated for a mycotic aortic aneurysm secondary to C. septicum bacteremia. Subsequent evaluation confirmed a colonic malignancy, prompting early intervention. A systematic literature review revealing a rate of gastrointestinal malignancy in this patient population is 71%, hematologic malignancy is 3.9%, with the remaining cohort of patients having an unknown source. Infectious involvement of the aorta and associated vascular structures portends a poor prognosis with a 57% mortality rate. Our case and updated review demonstrates the implications of C. septicum vascular seeding and subsequent treatment outcomes.Copyright (C) 2017 Elsevier Inc. All rights reserved.All authors: Alimi Y, Borsinger TM, Espinel CF, Garrett JR, Salameh JR, Sosin MFiscal year: FY2017Digital Object Identifier: Date added to catalog: 2017-05-24
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 28479472 Available 28479472

Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007

Clostridium septicum is a rare organism, accounting for approximately 1.3% of clostridial infections and is associated with synchronous colonic malignancy. This case report describes a patient successfully treated for a mycotic aortic aneurysm secondary to C. septicum bacteremia. Subsequent evaluation confirmed a colonic malignancy, prompting early intervention. A systematic literature review revealing a rate of gastrointestinal malignancy in this patient population is 71%, hematologic malignancy is 3.9%, with the remaining cohort of patients having an unknown source. Infectious involvement of the aorta and associated vascular structures portends a poor prognosis with a 57% mortality rate. Our case and updated review demonstrates the implications of C. septicum vascular seeding and subsequent treatment outcomes.

Copyright (C) 2017 Elsevier Inc. All rights reserved.

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