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Treatment of advanced group 2 PH. [Review]

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Citation: Progress in Cardiovascular Diseases. 59(1):78-86, 2016 Jul-AugPMID: 27417251Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Disease Management | *Heart Failure/co [Complications] | *Heart Transplantation | *Hypertension, Pulmonary/th [Therapy] | *Vascular Resistance/ph [Physiology] | Humans | Hypertension, Pulmonary/et [Etiology] | Hypertension, Pulmonary/pp [Physiopathology]Year: 2016 Local holdings: Available in print through MWHC library: 2004 - 2006ISSN:

0033-0620

Name of journal: Progress in cardiovascular diseasesAbstract: Copyright 2016. Published by Elsevier Inc.Pulmonary hypertension (PH) frequently occurs in patients with left heart disease (LHD), including heart failure with reduced and preserved ejection fraction and valvular heart disease. PH in patients with LHD is associated with worse outcomes making it an attractive target of therapy. Despite the strong rational for treatment, no clear benefits from treating with pulmonary arterial hypertension specific therapies in patients with PH from LHD have been found in clinical trials and some studies have demonstrated harm. Therefore, PH in the setting of LHD should be managed with optimal medical and surgical treatment of LHD and identification and treatment of comorbidities that could contribute to PH. Additionally, significant PH is a contraindication to heart transplantation and, in select patients with left heart failure, left ventricular unloading with prolonged inotrope infusion or left ventricular assist device implantation may successfully reduce pulmonary artery pressures and facilitate transplantation. All authors: Barnett CF, De Marco TFiscal year: FY2017Digital Object Identifier:

https://dx.doi.org/10.1016/j.pcad.2016.07.002

Date added to catalog: 2017-04-11

Holdings ( 1 )
Title notes ( 4 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	27417251	Available		27417251

Available in print through MWHC library: 2004 - 2006

Pulmonary hypertension (PH) frequently occurs in patients with left heart disease (LHD), including heart failure with reduced and preserved ejection fraction and valvular heart disease. PH in patients with LHD is associated with worse outcomes making it an attractive target of therapy. Despite the strong rational for treatment, no clear benefits from treating with pulmonary arterial hypertension specific therapies in patients with PH from LHD have been found in clinical trials and some studies have demonstrated harm. Therefore, PH in the setting of LHD should be managed with optimal medical and surgical treatment of LHD and identification and treatment of comorbidities that could contribute to PH. Additionally, significant PH is a contraindication to heart transplantation and, in select patients with left heart failure, left ventricular unloading with prolonged inotrope infusion or left ventricular assist device implantation may successfully reduce pulmonary artery pressures and facilitate transplantation.

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