Rates of recurrent preterm birth by maternal body habitus in women receiving 17alpha-hydroxyprogesterone caproate.

MedStar author(s):
Citation: Journal of Maternal-Fetal & Neonatal Medicine. 26(9):881-4, 2013 Jun.PMID: 23311766Institution: MedStar Washington Hospital CenterDepartment: Obstetrics and Gynecology/Maternal-Fetal MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Body Mass Index | *Hydroxyprogesterones/ad [Administration & Dosage] | *Premature Birth/ep [Epidemiology] | *Premature Birth/pc [Prevention & Control] | *Progesterone Congeners/ad [Administration & Dosage] | Adult | Cohort Studies | Female | Humans | Infant, Newborn | Obesity/co [Complications] | Obesity/ep [Epidemiology] | Pregnancy | Pregnancy Complications/ep [Epidemiology] | Recurrence | Retrospective Studies | Young AdultYear: 2013Local holdings: Available online through MWHC library: 2013 to the presentISSN:
  • 1476-4954
Name of journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansAbstract: CONCLUSIONS: Recurrent spontaneous preterm delivery<37 weeks in patients on 17P is more common in lean women (BMI<18.5kg/m(2)), and less common in obese women (BMI >30kg/m(2)) suggesting that the current recommended dosing of 17P is adequate for women with higher BMI.METHODS: Retrospective analysis of a cohort of 6253 women with a singleton gestation and prior SPTB enrolled in 17P home administration program between 16.0 and 26.9 weeks. Data were grouped by pre-pregnancy BMI (lean <18.5kg/m(2), normal 18.5-24.9kg/m(2), overweight 25-29.9kg/m(2) and obese >30.0kg/m(2)). Delivery outcomes were compared using chi(2) and Kruskal-Wallis tests with statistical significance set at p<0.05.OBJECTIVE: To examine the influence of maternal pre-pregnancy body mass index (BMI) on the rates of recurrent spontaneous preterm birth (SPTB) in women receiving 17alpha-hydroxyprogesterone caproate (17P).RESULTS: SPTB<28 weeks was significantly lower in normal weight women. Rates of recurrent SPTB<37 weeks were highest in the group with BMI<18.5kg/m(2). Lean gravidas were younger, more likely to smoke, and less likely to be African-American than those with normal or increased BMI. In logistic regression, after controlling for race and prior preterm birth <28 weeks, the risk of SPTB<37 weeks decreased 2% for every additional 1kg/m(2) increase in BMI.All authors: Boyle A, Driggers RW, Feghali M, Istwan N, Rhea D, Timofeev JFiscal year: FY2013Digital Object Identifier: Date added to catalog: 2014-02-24
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 23311766 Available 23311766

Available online through MWHC library: 2013 to the present

CONCLUSIONS: Recurrent spontaneous preterm delivery<37 weeks in patients on 17P is more common in lean women (BMI<18.5kg/m(2)), and less common in obese women (BMI >30kg/m(2)) suggesting that the current recommended dosing of 17P is adequate for women with higher BMI.

METHODS: Retrospective analysis of a cohort of 6253 women with a singleton gestation and prior SPTB enrolled in 17P home administration program between 16.0 and 26.9 weeks. Data were grouped by pre-pregnancy BMI (lean <18.5kg/m(2), normal 18.5-24.9kg/m(2), overweight 25-29.9kg/m(2) and obese >30.0kg/m(2)). Delivery outcomes were compared using chi(2) and Kruskal-Wallis tests with statistical significance set at p<0.05.

OBJECTIVE: To examine the influence of maternal pre-pregnancy body mass index (BMI) on the rates of recurrent spontaneous preterm birth (SPTB) in women receiving 17alpha-hydroxyprogesterone caproate (17P).

RESULTS: SPTB<28 weeks was significantly lower in normal weight women. Rates of recurrent SPTB<37 weeks were highest in the group with BMI<18.5kg/m(2). Lean gravidas were younger, more likely to smoke, and less likely to be African-American than those with normal or increased BMI. In logistic regression, after controlling for race and prior preterm birth <28 weeks, the risk of SPTB<37 weeks decreased 2% for every additional 1kg/m(2) increase in BMI.

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