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A woman with warts, leg swelling, and deafness.

MedStar author(s):

Citation: Journal of the American Academy of Dermatology. 71(3):577-80, 2014 Sep.PMID: 25128101Institution: MedStar Washington Hospital CenterDepartment: DermatologyForm of publication: Journal ArticleMedline article type(s): Case Reports | Journal Article | Research Support, N.I.H., IntramuralSubject headings: *GATA2 Transcription Factor/df [Deficiency] | *Hearing Loss, Sensorineural/im [Immunology] | *Immunologic Deficiency Syndromes/di [Diagnosis] | *Lymphedema/im [Immunology] | *Warts/im [Immunology] | Female | Humans | Middle AgedLocal holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006ISSN:

0190-9622

Name of journal: Journal of the American Academy of DermatologyAbstract: KEY TEACHING POINTS * We describe a 45-year-old woman with GATA2 deficiency associated with verrucae, lymphedema, immunodeficiency, and a history of infections and skin cancer. * GATA2 deficiency has variable clinical expressivity with differing presentations, including infection, hematopoietic abnormalities, immunodeficiency, lymphedema, and cancer. * Cutaneous manifestations include verruca vulgaris, soft tissue infections, lymphedema, and panniculitis. * Patients may have verrucae that can progress to squamous cell carcinomas; dermatologists therefore play an important role in managing these patients as members of a multidisciplinary team. Copyright Published by Mosby, Inc.All authors: Holland SM, Kong HH, Muszynski MA, Zerbe CSDigital Object Identifier:

http://dx.doi.org/10.1016/j.jaad.2014.04.027

Date added to catalog: 2015-03-17

Holdings ( 1 )
Title notes ( 3 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article		Available		25128101

Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006

KEY TEACHING POINTS * We describe a 45-year-old woman with GATA2 deficiency associated with verrucae, lymphedema, immunodeficiency, and a history of infections and skin cancer. * GATA2 deficiency has variable clinical expressivity with differing presentations, including infection, hematopoietic abnormalities, immunodeficiency, lymphedema, and cancer. * Cutaneous manifestations include verruca vulgaris, soft tissue infections, lymphedema, and panniculitis. * Patients may have verrucae that can progress to squamous cell carcinomas; dermatologists therefore play an important role in managing these patients as members of a multidisciplinary team. Copyright Published by Mosby, Inc.

English