Patient characteristics in variable left ventricular recovery from Takotsubo syndrome.

MedStar author(s):
Citation: Cardiovascular Revascularization Medicine. 19(3 Pt A):247-250, 2018 04.PMID: 29153508Institution: MedStar Heart & Vascular Institute | MedStar Washington Hospital CenterDepartment: Medicine/Internal MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Stroke Volume | *Takotsubo Cardiomyopathy/pp [Physiopathology] | *Ventricular Function, Left | Action Potentials | Age Factors | Aged | Aged, 80 and over | Comorbidity | Echocardiography | Electrocardiography | Female | Heart Rate | Humans | Hypothyroidism/ep [Epidemiology] | Male | Middle Aged | Prevalence | Recovery of Function | Registries | Retrospective Studies | Takotsubo Cardiomyopathy/di [Diagnosis] | Takotsubo Cardiomyopathy/ep [Epidemiology] | Takotsubo Cardiomyopathy/th [Therapy] | Time Factors | United States/ep [Epidemiology]Year: 2018Local holdings: Available in print through MWHC library: 2002 - presentISSN:
  • 1878-0938
Name of journal: Cardiovascular revascularization medicine : including molecular interventionsAbstract: BACKGROUND: Takotsubo syndrome (TTS) is a heart failure syndrome which is usually reversible. Factors associated with degree of recovery of left ventricular systolic function in TTS are poorly understood.CONCLUSION: Takotsubo patients with partial myocardial recovery were older, presented with longer QT intervals, and were more likely to have comorbid hypothyroidism.Copyright (c) 2017 Elsevier Inc. All rights reserved.MATERIALS AND METHODS: We conducted a retrospective analysis of 90 TTS patients treated at our institution from 2006 to 2014. Patients were grouped based on recovery of left ventricular ejection fraction (LVEF) on follow-up transthoracic echocardiogram as left ventricular ejection fraction <50% (partial group) or preserved ejection fraction >=50% (full group). Patient baseline characteristics, comorbidities, biomarkers, electrocardiography, and echocardiogram were collected. We also compared adverse events that occurred during hospitalization.RESULTS: In comparison to full recovery group patients (n=63), partial recovery patients (n=27) were older (76.9+/-13 vs. 70.6+/-13years; P=0.02) and had a higher prevalence of comorbid hypothyroidism (26% vs. 8%; P=0.02). A greater number of patients from the partial group were also taking levothyroxine replacement (22% vs. 3%; P=0.003). We found no significant between-group differences in type of triggering event or cardiac biomarker levels. QT interval was longer in the partial group (540.6+/-71msec vs. 460.7+/-35msec; P=0.01). Follow-up LVEF was 37.9+/-8% in the partial group and 58.0+/-4% in the full group (P<0.001). There were no statistically significant differences in length of stay or adverse events.All authors: Azzouqa A, Ben-Dor I, Kim JI, Koiffman E, Lindsay J, Moran J, Pichard AD, Satler LF, Torguson R, Waksman R, Wang Z, Weissman G, Yerasi CFiscal year: FY2018Digital Object Identifier: Date added to catalog: 2017-12-05
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 29153508 Available 29153508

Available in print through MWHC library: 2002 - present

BACKGROUND: Takotsubo syndrome (TTS) is a heart failure syndrome which is usually reversible. Factors associated with degree of recovery of left ventricular systolic function in TTS are poorly understood.

CONCLUSION: Takotsubo patients with partial myocardial recovery were older, presented with longer QT intervals, and were more likely to have comorbid hypothyroidism.

Copyright (c) 2017 Elsevier Inc. All rights reserved.

MATERIALS AND METHODS: We conducted a retrospective analysis of 90 TTS patients treated at our institution from 2006 to 2014. Patients were grouped based on recovery of left ventricular ejection fraction (LVEF) on follow-up transthoracic echocardiogram as left ventricular ejection fraction <50% (partial group) or preserved ejection fraction >=50% (full group). Patient baseline characteristics, comorbidities, biomarkers, electrocardiography, and echocardiogram were collected. We also compared adverse events that occurred during hospitalization.

RESULTS: In comparison to full recovery group patients (n=63), partial recovery patients (n=27) were older (76.9+/-13 vs. 70.6+/-13years; P=0.02) and had a higher prevalence of comorbid hypothyroidism (26% vs. 8%; P=0.02). A greater number of patients from the partial group were also taking levothyroxine replacement (22% vs. 3%; P=0.003). We found no significant between-group differences in type of triggering event or cardiac biomarker levels. QT interval was longer in the partial group (540.6+/-71msec vs. 460.7+/-35msec; P=0.01). Follow-up LVEF was 37.9+/-8% in the partial group and 58.0+/-4% in the full group (P<0.001). There were no statistically significant differences in length of stay or adverse events.

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