Severe functional mitral stenosis due to a left atrial myxoma masquerading as asthma.

MedStar author(s):
Citation: BMJ Case Reports. 13(12), 2020 Dec 17.PMID: 33334748Institution: MedStar Franklin Square Medical Center | MedStar Heart & Vascular Institute | MedStar Union Memorial HospitalDepartment: PathologyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Dyspnea/et [Etiology] | *Heart Neoplasms/di [Diagnosis] | *Mitral Valve Stenosis/di [Diagnosis] | *Myxoma/di [Diagnosis] | Asthma/di [Diagnosis] | Cardiopulmonary Bypass | Computed Tomography Angiography | Diagnosis, Differential | Dyspnea/su [Surgery] | Echocardiography | Electrocardiography | Female | Heart Atria/dg [Diagnostic Imaging] | Heart Atria/pa [Pathology] | Heart Neoplasms/co [Complications] | Heart Neoplasms/pa [Pathology] | Heart Neoplasms/su [Surgery] | Humans | Middle Aged | Mitral Valve Stenosis/et [Etiology] | Mitral Valve Stenosis/su [Surgery] | Myxoma/co [Complications] | Myxoma/pa [Pathology] | Myxoma/su [Surgery] | Sternotomy | Treatment OutcomeYear: 2020ISSN:
  • 1757-790X
Name of journal: BMJ case reportsAbstract: While cardiac myxomas are the most common primary cardiac tumours, their overall incidence remains rare. Most cases (90%) are sporadic and occur in the third-sixth decades of life with a female predominance and have a specific predilection for the left atrium (75%). While often asymptomatic, clinical presentations depend on the tumour size, architecture and location. Echocardiography remains the mainstay for diagnostic evaluation. Tumour resection is the only definitive treatment. Histopathology using H&E and immunohistochemical stains, such as calretinin and CD34, confirms the diagnosis. We present a case of a patient with reported history of asthma who presented with recurrent acute on chronic shortness of breath refractory to inhaler therapy, multiple outpatient visits and hospitalisations for 'asthma exacerbations'. After further evaluation, she was diagnosed with a left atrial myxoma attached to the inferior aspect of the intra-atrial septum complicated by severe functional mitral stenosis. Copyright (c) BMJ Publishing Group Limited 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.All authors: Allen E, Haas C, Quarrie R, Zuwasti UOriginally published: BMJ Case Reports. 13(12), 2020 Dec 17.Fiscal year: FY2021Digital Object Identifier: ORCID: Date added to catalog: 2020-12-31
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Journal Article MedStar Authors Catalog Article 33334748 Available 33334748

While cardiac myxomas are the most common primary cardiac tumours, their overall incidence remains rare. Most cases (90%) are sporadic and occur in the third-sixth decades of life with a female predominance and have a specific predilection for the left atrium (75%). While often asymptomatic, clinical presentations depend on the tumour size, architecture and location. Echocardiography remains the mainstay for diagnostic evaluation. Tumour resection is the only definitive treatment. Histopathology using H&E and immunohistochemical stains, such as calretinin and CD34, confirms the diagnosis. We present a case of a patient with reported history of asthma who presented with recurrent acute on chronic shortness of breath refractory to inhaler therapy, multiple outpatient visits and hospitalisations for 'asthma exacerbations'. After further evaluation, she was diagnosed with a left atrial myxoma attached to the inferior aspect of the intra-atrial septum complicated by severe functional mitral stenosis. Copyright (c) BMJ Publishing Group Limited 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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