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An analysis of the association between statin use and risk of endometrial and ovarian cancers in the Women's Health Initiative.

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Citation: Gynecologic Oncology. 148(3):540-546, 2018 03.PMID: 29422345Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Adenocarcinoma, Clear Cell/ep [Epidemiology] | *Carcinoma, Endometrioid/ep [Epidemiology] | *Carcinosarcoma/ep [Epidemiology] | *Endometrial Neoplasms/ep [Epidemiology] | *Hydroxymethylglutaryl-CoA Reductase Inhibitors/tu [Therapeutic Use] | *Neoplasms, Cystic, Mucinous, and Serous/ep [Epidemiology] | *Ovarian Neoplasms/ep [Epidemiology] | Adenocarcinoma, Mucinous/ep [Epidemiology] | Aged | Female | Humans | Middle Aged | Postmenopause | Pravastatin/tu [Therapeutic Use] | Proportional Hazards Models | Risk Factors | United States/ep [Epidemiology] | Women's HealthYear: 2018 Local holdings: Available online from MWHC library: 1972 - presentISSN:

0090-8258

Name of journal: Gynecologic oncologyAbstract: BACKGROUND: Statins have anti proliferative activity in vitro against endometrial and ovarian cancer and can affect levels of reproductive hormones. We analyzed data from the Women's Health Initiative (WHI) to assess whether statins are associated with risk of endometrial and ovarian cancer.CONCLUSIONS: There was a reduction in risk of endometrial cancer among statin users at baseline but not in time-dependent models. Pravastatin use was associated with an increased risk of ovarian cancer. Analyses of larger numbers of cases are needed to evaluate these findings.Copyright (c) 2018. Published by Elsevier Inc.METHODS: The WHI study included 161,808 postmenopausal women in which incident cases of endometrial (n=1377) and ovarian cancer (n=763) were identified over an average of 10.8 (SD+3.3) years. Information on statin use and risk factors was collected at baseline and follow-up. Cox proportional hazards regression was used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) for the association of statin use and risk of endometrial and ovarian cancer. All statistical tests were two-sided.RESULTS: Statins were used at baseline by 7.5% women and by up to 25% at year nine. The multivariable adjusted HR for risk of endometrial cancer for baseline statin use was 0.74, 95% C.I. 0.59-0.94 and for ovarian cancer was 1.15, 95% C.I. 0.89-1.50. In time-dependent models, statins were not associated with endometrial cancer (HR 0.91, 95% C.I. 0.76-1.08) however there was an increased risk of ovarian cancer (HR 1.30, 95% CI 1.04-1.62), largely attributed to the effect of the hydrophilic statin, pravastatin (1.89, 95% CI 1.24-2.88).All authors: Anderson ML, Desai P, Howard BV, Manson JE, Martin LW, Ray RM, Rohan T, Safford M, Simon MS, Wallace R, Wu COriginally published: Gynecologic Oncology. 2018 Feb 05Fiscal year: FY2018Digital Object Identifier:

https://dx.doi.org/10.1016/j.ygyno.2018.01.006

Date added to catalog: 2018-02-20

Holdings ( 1 )
Title notes ( 7 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	29422345	Available		29422345

Available online from MWHC library: 1972 - present

BACKGROUND: Statins have anti proliferative activity in vitro against endometrial and ovarian cancer and can affect levels of reproductive hormones. We analyzed data from the Women's Health Initiative (WHI) to assess whether statins are associated with risk of endometrial and ovarian cancer.

CONCLUSIONS: There was a reduction in risk of endometrial cancer among statin users at baseline but not in time-dependent models. Pravastatin use was associated with an increased risk of ovarian cancer. Analyses of larger numbers of cases are needed to evaluate these findings.

METHODS: The WHI study included 161,808 postmenopausal women in which incident cases of endometrial (n=1377) and ovarian cancer (n=763) were identified over an average of 10.8 (SD+3.3) years. Information on statin use and risk factors was collected at baseline and follow-up. Cox proportional hazards regression was used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) for the association of statin use and risk of endometrial and ovarian cancer. All statistical tests were two-sided.

RESULTS: Statins were used at baseline by 7.5% women and by up to 25% at year nine. The multivariable adjusted HR for risk of endometrial cancer for baseline statin use was 0.74, 95% C.I. 0.59-0.94 and for ovarian cancer was 1.15, 95% C.I. 0.89-1.50. In time-dependent models, statins were not associated with endometrial cancer (HR 0.91, 95% C.I. 0.76-1.08) however there was an increased risk of ovarian cancer (HR 1.30, 95% CI 1.04-1.62), largely attributed to the effect of the hydrophilic statin, pravastatin (1.89, 95% CI 1.24-2.88).

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