Topical therapy for refractory rhinosinusitis caused by methicillin-resistant Staphylococcus aureus: First report in a prospective series.

MedStar author(s):
Citation: Auris, Nasus, Larynx. 45(5):994-999, 2018 Oct.PMID: 29426723Institution: MedStar Union Memorial HospitalDepartment: Maryland Nose & Sinus CenterForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Anti-Bacterial Agents/ad [Administration & Dosage] | *Rhinitis/dt [Drug Therapy] | *Sinusitis/dt [Drug Therapy] | *Staphylococcal Infections/dt [Drug Therapy] | Administration, Intranasal | Administration, Topical | Adult | Aged | Anti-Inflammatory Agents/ad [Administration & Dosage] | Cellulose/aa [Analogs & Derivatives] | Culture Techniques | Debridement | Endoscopy | Female | Humans | Instillation, Drug | Male | Methicillin-Resistant Staphylococcus aureus | Microbial Sensitivity Tests | Middle Aged | Mometasone Furoate/ad [Administration & Dosage] | Mupirocin/ad [Administration & Dosage] | Nebulizers and Vaporizers | Prospective Studies | Rhinitis/mi [Microbiology] | Rhinitis/su [Surgery] | Sinusitis/mi [Microbiology] | Sinusitis/su [Surgery] | Staphylococcal Infections/mi [Microbiology] | Staphylococcal Infections/su [Surgery] | Therapeutic Irrigation | Tobramycin/ad [Administration & Dosage] | Treatment Outcome | Vancomycin/ad [Administration & Dosage]Year: 2018Local holdings: Available online through MWHC library: 2008 - presentISSN:
  • 0385-8146
Name of journal: Auris, nasus, larynxAbstract: CONCLUSION: Our findings demonstrate that topical therapy is an effective method for treating MRSA-associated refractory CRS.Copyright (c) 2018. Published by Elsevier B.V.METHODS: Seventeen patients with refractory CRS caused by MRSA were treated with a topical therapy protocol. Treatment consisted of weekly endoscopic sinus debridement followed by intra-sinus installation of a hydroxyl-ethylcellulose gel that releases mometasone and a culture-directed antibiotic for a period of 6 weeks, along with daily nasal nebulization of mometasone with the same antibiotic and saline rinses. Clinical outcome was assessed using the Lund-Kennedy (LK) symptom and endoscopic appearance scores. Sinus mucosal tissue was homogenized and cultured, and microbial biofilm burden was assessed based on colony forming units (CFUs) counts.OBJECTIVE: The incidence of refractory chronic rhinosinusitis (CRS) associated with methicillin-resistant Staphylococcus aureus (MRSA) is rising and remains a therapeutic challenge. The goal of this study is to demonstrate the efficacy of a non-invasive topical therapy against MRSA in these patients.RESULTS: Rhinotopic therapy resulted in clearance of MRSA in 13 of 16 patients (81.2%). Treated patients also demonstrated significant improvement clinically as measured by the LK scores. In addition, a significant decrease in mucosal CFUs was observed post-therapy.All authors: Basaraba RJ, Jabra-Rizk MA, Khoueir N, Leid JG, Shikani AH, Shikani HJFiscal year: FY2019Fiscal year of original publication: FY2018Digital Object Identifier: Date added to catalog: 2018-02-20
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 29426723 Available 29426723

Available online through MWHC library: 2008 - present

CONCLUSION: Our findings demonstrate that topical therapy is an effective method for treating MRSA-associated refractory CRS.

Copyright (c) 2018. Published by Elsevier B.V.

METHODS: Seventeen patients with refractory CRS caused by MRSA were treated with a topical therapy protocol. Treatment consisted of weekly endoscopic sinus debridement followed by intra-sinus installation of a hydroxyl-ethylcellulose gel that releases mometasone and a culture-directed antibiotic for a period of 6 weeks, along with daily nasal nebulization of mometasone with the same antibiotic and saline rinses. Clinical outcome was assessed using the Lund-Kennedy (LK) symptom and endoscopic appearance scores. Sinus mucosal tissue was homogenized and cultured, and microbial biofilm burden was assessed based on colony forming units (CFUs) counts.

OBJECTIVE: The incidence of refractory chronic rhinosinusitis (CRS) associated with methicillin-resistant Staphylococcus aureus (MRSA) is rising and remains a therapeutic challenge. The goal of this study is to demonstrate the efficacy of a non-invasive topical therapy against MRSA in these patients.

RESULTS: Rhinotopic therapy resulted in clearance of MRSA in 13 of 16 patients (81.2%). Treated patients also demonstrated significant improvement clinically as measured by the LK scores. In addition, a significant decrease in mucosal CFUs was observed post-therapy.

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