Statistical genetic analysis of serological measures of common, chronic infections in Alaska Native participants in the GOCADAN study.

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Citation: Genetic Epidemiology. 37(7):751-7, 2013 Nov.PMID: 23798484Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov'tSubject headings: *Antibodies, Bacterial/bl [Blood] | *Antibodies, Viral/bl [Blood] | *Coronary Artery Disease/ge [Genetics] | *Health Surveys | *Indians, North American/ge [Genetics] | *Infection/ge [Genetics] | *Infection/im [Immunology] | Adolescent | Adult | Age Factors | Aged | Aged, 80 and over | Alaska | C-Reactive Protein/an [Analysis] | Chlamydophila pneumoniae/im [Immunology] | Chlamydophila pneumoniae/ip [Isolation & Purification] | Chromosomes, Human, Pair 15/ge [Genetics] | Chronic Disease | Coronary Artery Disease/mi [Microbiology] | Coronary Artery Disease/vi [Virology] | Cytomegalovirus/im [Immunology] | Cytomegalovirus/ip [Isolation & Purification] | Female | Genetic Linkage/ge [Genetics] | Genetic Predisposition to Disease/ge [Genetics] | Genome, Human/ge [Genetics] | Helicobacter pylori/im [Immunology] | Helicobacter pylori/ip [Isolation & Purification] | Herpesvirus 1, Human/im [Immunology] | Herpesvirus 1, Human/ip [Isolation & Purification] | Herpesvirus 2, Human/im [Immunology] | Herpesvirus 2, Human/ip [Isolation & Purification] | Humans | Immunoglobulin G/bl [Blood] | Infection/mi [Microbiology] | Infection/vi [Virology] | Lod Score | Male | Middle Aged | Pedigree | Seroepidemiologic Studies | Serologic Tests | Time Factors | Young AdultYear: 2013ISSN:
  • 0741-0395
Name of journal: Genetic epidemiologyAbstract: This paper describes genetic investigations of seroreactivity to five common infectious pathogens in the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. Antibody titers and seroprevalence were available for 495 to 782 (depending on the phenotype) family members at two time points, approximately 15 years apart, for Chlamydophila pneumoniae, Helicobacter pylori, cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and herpes simplex virus 2 (HSV-2). Seroprevalence rates indicate that infections with most of these pathogens are common (>20% for all of them, >80% for H. pylori, CMV, and HSV-1). Seropositive individuals typically remain seropositive over time, with seroreversion rates of <1% to 10% over ~15 years. Antibody titers were significantly heritable for most pathogens, with the highest estimate being 0.61 for C. pneumoniae. Significant genome-wide linkage evidence was obtained for C. pneumoniae on chromosome 15 (logarithm of odds, LOD score of 3.13). These results demonstrate that individual host genetic differences influence antibody measures of common infections in this population, and further investigation may elucidate the underlying immunological processes and genes involved. 2013 WILEY PERIODICALS, INC.All authors: Cole SA, Comuzzie AG, Davidson M, Ebbesson SO, Goring HH, Howard BV, Laston S, Maccluer JW, Rubicz R, Umans JG, Voruganti VS, Zhu JFiscal year: FY2014Digital Object Identifier: Date added to catalog: 2014-08-21
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Journal Article MedStar Authors Catalog Article 23798484 Available 23798484

This paper describes genetic investigations of seroreactivity to five common infectious pathogens in the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. Antibody titers and seroprevalence were available for 495 to 782 (depending on the phenotype) family members at two time points, approximately 15 years apart, for Chlamydophila pneumoniae, Helicobacter pylori, cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and herpes simplex virus 2 (HSV-2). Seroprevalence rates indicate that infections with most of these pathogens are common (>20% for all of them, >80% for H. pylori, CMV, and HSV-1). Seropositive individuals typically remain seropositive over time, with seroreversion rates of <1% to 10% over ~15 years. Antibody titers were significantly heritable for most pathogens, with the highest estimate being 0.61 for C. pneumoniae. Significant genome-wide linkage evidence was obtained for C. pneumoniae on chromosome 15 (logarithm of odds, LOD score of 3.13). These results demonstrate that individual host genetic differences influence antibody measures of common infections in this population, and further investigation may elucidate the underlying immunological processes and genes involved. 2013 WILEY PERIODICALS, INC.

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