Gestational diabetes: implications for cardiovascular health. [Review]

MedStar author(s):
Citation: Current Diabetes Reports. 12(1):43-52, 2012 Feb.PMID: 22037824Institution: MedStar Health Research Institute | MedStar Washington Hospital CenterDepartment: Medicine/EndocrinologyForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Cardiovascular Diseases/et [Etiology] | *Diabetes Mellitus, Type 2/co [Complications] | *Diabetes, Gestational | *Diabetic Angiopathies/et [Etiology] | *Obesity/co [Complications] | Biological Markers/bl [Blood] | Cardiovascular Diseases/dt [Drug Therapy] | Cardiovascular Diseases/pc [Prevention & Control] | Diabetes Complications/et [Etiology] | Diabetes Mellitus, Type 2/dt [Drug Therapy] | Diabetes Mellitus, Type 2/pc [Prevention & Control] | Diabetes, Gestational/dt [Drug Therapy] | Diabetes, Gestational/pc [Prevention & Control] | Diabetic Angiopathies/dt [Drug Therapy] | Diabetic Angiopathies/pc [Prevention & Control] | Disease Progression | Female | Humans | Hypoglycemic Agents/tu [Therapeutic Use] | Maternal Age | Metformin/tu [Therapeutic Use] | Obesity/pc [Prevention & Control] | Pregnancy | Prevalence | Risk Assessment | Risk FactorsYear: 2012ISSN:
  • 1534-4827
Name of journal: Current diabetes reportsAbstract: Gestational diabetes mellitus (GDM) is a pregnancy complication that is becoming more prevalent with recent population trends in obesity and advancing maternal age. A diagnosis of GDM not only increases risk for maternal and fetal complications during pregnancy, but also significantly increases a woman's risk of both type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in the postpartum. Even women with milder forms of abnormal glucose homeostasis during pregnancy, specifically gestational impaired glucose tolerance, are at increased risk, justifying the recent recommendation to tighten the diagnostic criteria for GDM, thus implicating many more women. Risk factors that increase risk for future CVD among women with a history of GDM include postpartum progression to T2DM; metabolic syndrome; obesity; hypertension; and altered levels of circulating inflammatory markers, specifically, adiponectin, C-reactive protein, and tumor necrosis factor-. Medical therapies such as metformin that prevent progression to T2DM may prove to be our primary defense against earlier CVD among women with GDM.All authors: Ratner R, Sullivan SD, Umans JGFiscal year: FY2012Digital Object Identifier: Date added to catalog: 2013-09-17
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Journal Article MedStar Authors Catalog Article 22037824 Available 22037824

Gestational diabetes mellitus (GDM) is a pregnancy complication that is becoming more prevalent with recent population trends in obesity and advancing maternal age. A diagnosis of GDM not only increases risk for maternal and fetal complications during pregnancy, but also significantly increases a woman's risk of both type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in the postpartum. Even women with milder forms of abnormal glucose homeostasis during pregnancy, specifically gestational impaired glucose tolerance, are at increased risk, justifying the recent recommendation to tighten the diagnostic criteria for GDM, thus implicating many more women. Risk factors that increase risk for future CVD among women with a history of GDM include postpartum progression to T2DM; metabolic syndrome; obesity; hypertension; and altered levels of circulating inflammatory markers, specifically, adiponectin, C-reactive protein, and tumor necrosis factor-. Medical therapies such as metformin that prevent progression to T2DM may prove to be our primary defense against earlier CVD among women with GDM.

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