Obatoclax mesylate, a pan-bcl-2 inhibitor, in combination with docetaxel in a phase 1/2 trial in relapsed non-small-cell lung cancer.

MedStar author(s):
Citation: Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer. 9(1):121-5, 2014 Jan.PMID: 24346101Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Clinical Trial, Phase I | Clinical Trial, Phase II | Journal Article | Research Support, Non-U.S. Gov'tSubject headings: *Antineoplastic Combined Chemotherapy Protocols/tu [Therapeutic Use] | *Carcinoma, Non-Small-Cell Lung/dt [Drug Therapy] | *Lung Neoplasms/dt [Drug Therapy] | *Neoplasm Recurrence, Local/dt [Drug Therapy] | Carcinoma, Non-Small-Cell Lung/mo [Mortality] | Humans | Lung Neoplasms/mo [Mortality] | Maximum Tolerated Dose | Neoplasm Recurrence, Local/mo [Mortality] | Pyrroles/ad [Administration & Dosage] | Pyrroles/ae [Adverse Effects] | Pyrroles/pk [Pharmacokinetics] | Taxoids/ad [Administration & Dosage] | Taxoids/ae [Adverse Effects] | Taxoids/pk [Pharmacokinetics]Year: 2014Local holdings: Available online through MWHC library: 2006 - presentISSN:
  • 1556-0864
Name of journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung CancerAbstract: CONCLUSIONS: Combined obatoclax mesylate plus docetaxel is tolerable in patients with NSCLC, but response was minimal and neutropenia was a common adverse event.INTRODUCTION: The proapoptotic small-molecule pan-Bcl-2 inhibitor obatoclax mesylate (GX15-070) may enhance the cytotoxicity of chemotherapy in relapsed/refractory non-small-cell lung cancer (NSCLC).METHODS: Obatoclax was administered with docetaxel in patients with relapsed or refractory NSCLC- docetaxel as a 1-hour infusion on day 1 and obatoclax as a 24-hour infusion on days 1 and 2-every 3 weeks for up to eight cycles. Four dose levels were evaluated in phase 1 (level 1: docetaxel 55 mg/m x 1 and obatoclax 30 mg x 2; levels 2-4: docetaxel 75 mg/m and obatoclax 30 mg, 45 mg, or 60 mg x 2) to identify dose-limiting toxicity and a phase 2 dose. In phase 2, response and tolerability were evaluated.RESULTS: Eighteen patients were included in phase 1. Two dose-limiting toxicities occurred during cycle 1: one febrile neutropenia each at dose levels 3 and 4. Maximum tolerated dose was not reached; 32 patients (including 3 from phase 1) were treated in phase 2 with docetaxel 75 mg/m and obatoclax 60 mg (median 2 cycles). Three patients (11%) had partial responses in phase 2; two demonstrated stable disease lasting 12 weeks or more. Median duration of response was 4.8 months. Overall, median progression-free survival was 1.4 months. Neutropenia (31%), febrile neutropenia (16%), and dyspnea (19%) were the most common grade 3/4 adverse events observed.All authors: Adams JW, Berger MS, Chiappori A, Edelman MJ, Haura EB, Malik S, Northfelt DW, Rosen P, Van Echo DA, Williams CFiscal year: FY2014Digital Object Identifier: Date added to catalog: 2014-11-11
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 24346101 Available 24346101

Available online through MWHC library: 2006 - present

CONCLUSIONS: Combined obatoclax mesylate plus docetaxel is tolerable in patients with NSCLC, but response was minimal and neutropenia was a common adverse event.

INTRODUCTION: The proapoptotic small-molecule pan-Bcl-2 inhibitor obatoclax mesylate (GX15-070) may enhance the cytotoxicity of chemotherapy in relapsed/refractory non-small-cell lung cancer (NSCLC).

METHODS: Obatoclax was administered with docetaxel in patients with relapsed or refractory NSCLC- docetaxel as a 1-hour infusion on day 1 and obatoclax as a 24-hour infusion on days 1 and 2-every 3 weeks for up to eight cycles. Four dose levels were evaluated in phase 1 (level 1: docetaxel 55 mg/m x 1 and obatoclax 30 mg x 2; levels 2-4: docetaxel 75 mg/m and obatoclax 30 mg, 45 mg, or 60 mg x 2) to identify dose-limiting toxicity and a phase 2 dose. In phase 2, response and tolerability were evaluated.

RESULTS: Eighteen patients were included in phase 1. Two dose-limiting toxicities occurred during cycle 1: one febrile neutropenia each at dose levels 3 and 4. Maximum tolerated dose was not reached; 32 patients (including 3 from phase 1) were treated in phase 2 with docetaxel 75 mg/m and obatoclax 60 mg (median 2 cycles). Three patients (11%) had partial responses in phase 2; two demonstrated stable disease lasting 12 weeks or more. Median duration of response was 4.8 months. Overall, median progression-free survival was 1.4 months. Neutropenia (31%), febrile neutropenia (16%), and dyspnea (19%) were the most common grade 3/4 adverse events observed.

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