Androgens, irregular menses, and risk of diabetes and coronary artery calcification in the Diabetes Prevention Program.

MedStar author(s):
Citation: Journal of Clinical Endocrinology & Metabolism. 103(2):486-496, 2018 02 01.PMID: 29220533Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Androgens/bl [Blood] | *Coronary Artery Disease/et [Etiology] | *Diabetes Mellitus/et [Etiology] | *Diabetes Mellitus/pc [Prevention & Control] | *Menstruation Disturbances/co [Complications] | *Polycystic Ovary Syndrome/th [Therapy] | *Vascular Calcification/et [Etiology] | Adult | Coronary Artery Disease/bl [Blood] | Coronary Artery Disease/ep [Epidemiology] | Diabetes Mellitus/bl [Blood] | Diabetes Mellitus/ep [Epidemiology] | Female | Humans | Menstruation Disturbances/ep [Epidemiology] | Middle Aged | Polycystic Ovary Syndrome/bl [Blood] | Polycystic Ovary Syndrome/co [Complications] | Preventive Health Services | Risk Factors | Vascular Calcification/bl [Blood] | Vascular Calcification/ep [Epidemiology]Year: 2018Local holdings: Available online through MWHC library: 1999- June 2013, Available in print through MWHC library: 1999 - 2006ISSN:
  • 0021-972X
Name of journal: The Journal of clinical endocrinology and metabolismAbstract: Conclusions: Among midlife women who were already glucose-intolerant and overweight, androgen concentrations and irregular menses did not additionally contribute to increased risk for diabetes or CAC.Context: It is unclear whether relative elevations in androgens or irregular menses (IM) are associated with greater cardiometabolic risk among women who are already overweight and glucose intolerant.Research Design and Methods: We conducted a secondary analysis of Diabetes Prevention Program (DPP) and the DPP Outcomes Study (DPPOS). Participants included women with sex hormone measurements who did not use exogenous estrogen (n=1422). We examined whether free androgen index (FAI) or IM were associated with diabetes risk during the DPP/DPPOS or with coronary artery calcification (CAC) at DPPOS year 10. Models were adjusted for menopausal status, age, race/ethnicity, randomization arm, body mass index (BMI), and hemoglobin A1c.Results: Women had an average age of 48.2+/-9.9 years. Elevations in FAI and IM were associated with greater BMI, waist circumference, blood pressure, and lower adiponectin. FAI was not associated with diabetes risk during the DPP/DPPOS (HR 0.97, 95% CI 0.93, 1.02) or increased odds of CAC (OR 1.06, 95% CI 0.92, 1.23). IM was also not associated with diabetes risk during the DPP/DPPOS (HR 1.07, 95% CI 0.87, 1.31) or increased odds of CAC (OR 0.89, 95 % CI 0.53, 1.49). Women who had both relative elevations in FAI as well as IM had similar diabetes risk and odds of CAC as women without these conditions. Differences by treatment arm and menopausal status were not observed.All authors: Aroda VR, Carrion-Petersen M, Diabetes Prevention Program Outcomes Study Group, Edelstein SL, Ehrmann DA, Goldberg RB, Kim C, Younes NFiscal year: FY2018Digital Object Identifier: Date added to catalog: 2017-12-20
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 29220533 Available 29220533

Available online through MWHC library: 1999- June 2013, Available in print through MWHC library: 1999 - 2006

Conclusions: Among midlife women who were already glucose-intolerant and overweight, androgen concentrations and irregular menses did not additionally contribute to increased risk for diabetes or CAC.

Context: It is unclear whether relative elevations in androgens or irregular menses (IM) are associated with greater cardiometabolic risk among women who are already overweight and glucose intolerant.

Research Design and Methods: We conducted a secondary analysis of Diabetes Prevention Program (DPP) and the DPP Outcomes Study (DPPOS). Participants included women with sex hormone measurements who did not use exogenous estrogen (n=1422). We examined whether free androgen index (FAI) or IM were associated with diabetes risk during the DPP/DPPOS or with coronary artery calcification (CAC) at DPPOS year 10. Models were adjusted for menopausal status, age, race/ethnicity, randomization arm, body mass index (BMI), and hemoglobin A1c.

Results: Women had an average age of 48.2+/-9.9 years. Elevations in FAI and IM were associated with greater BMI, waist circumference, blood pressure, and lower adiponectin. FAI was not associated with diabetes risk during the DPP/DPPOS (HR 0.97, 95% CI 0.93, 1.02) or increased odds of CAC (OR 1.06, 95% CI 0.92, 1.23). IM was also not associated with diabetes risk during the DPP/DPPOS (HR 1.07, 95% CI 0.87, 1.31) or increased odds of CAC (OR 0.89, 95 % CI 0.53, 1.49). Women who had both relative elevations in FAI as well as IM had similar diabetes risk and odds of CAC as women without these conditions. Differences by treatment arm and menopausal status were not observed.

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