000			02449nam a22004697a 4500
008			130916s20122012 xxu||||| |||| 00| 0 eng dOvid Technologies
040			_aOvid MEDLINE(R)
099			_a22492025
245			_aA review of genetics, arterial stiffness, and blood pressure in African Americans. [Review]
251			_aJournal of Cardiovascular Translational Research . 5(3):302-8, 2012 Jun.
252			_aJ Cardiovasc Transl Res. 5(3):302-8, 2012 Jun.
253			_aJournal of cardiovascular translational research
260			_c2012
260			_fFY2012
266			_d2013-09-17
520			_aThe prevalence of hypertension in African Americans in the USA is among the highest in the world and increasing. The identification of genes and pathways regulating blood pressure in African Americans has been challenging. An early predictor of hypertension is arterial stiffness. The prevalence of arterial stiffness is significantly higher in African Americans compared to Caucasians. Approximately 20 % of the variance in arterial stiffness is estimated to be heritable. Identifying genes and biological pathways regulating arterial stiffness may provide insight into the genetics underlying the increased risk of hypertension in African Americans. This paper reviews the genetic findings to date in the area of arterial stiffness and blood pressure in African Americans with an emphasis on the current limitations and new efforts to move the field forward.
546			_aEnglish
650			_a*African Americans/ge [Genetics]
650			_a*Arteries/pa [Pathology]
650			_a*Blood Pressure/ge [Genetics]
650			_a*Hypertension/ge [Genetics]
650			_aArteries/pp [Physiopathology]
650			_aCompliance
650			_aGenetic Predisposition to Disease
650			_aHeredity
650			_aHumans
650			_aHypertension/eh [Ethnology]
650			_aHypertension/pa [Pathology]
650			_aHypertension/pp [Physiopathology]
650			_aPhenotype
650			_aPrevalence
650			_aRisk Assessment
650			_aRisk Factors
650			_aUnited States/ep [Epidemiology]
651			_aMedStar Heart & Vascular Institute
657			_aJournal Article
657			_aReview
700			_aBarac, Ana
790			_aBarac A, Duprez DA, Hall JL, Rich SS
856			_uhttp://dx.doi.org/10.1007/s12265-012-9362-y _zhttp://dx.doi.org/10.1007/s12265-012-9362-y
942			_cART _dArticle
999			_c1053 _d1053