000			03114nam a22003737a 4500
008			220926s20222022 xxu||||| |||| 00| 0 eng d
022			_a1545-9683
024			_a10.1177/15459683221088861 [doi]
040			_aOvid MEDLINE(R)
099			_a35925037
245			_aBarriers to Enrollment in Post-Stroke Brain Stimulation in a Racially and Ethnically Diverse Population.
251			_aNeurorehabilitation & Neural Repair. :15459683221088861, 2022 Aug 04
252			_aNeurorehabil Neural Repair. :15459683221088861, 2022 Aug 04
253			_aNeurorehabilitation and neural repair
260			_c2022
260			_fFY2023
260			_p2022 Aug 04
265			_saheadofprint
266			_d2022-09-26
501			_aAvailable online from MWHC library: 2006 - 2009, Available in print through MWHC library: 1999 - March 2006
520			_aBACKGROUND AND PURPOSE: Brain stimulation is an adjuvant strategy to promote rehabilitation after stroke. Here, we evaluated the influence of inclusion/exclusion criteria on enrollment in a transcranial direct current stimulation (tDCS) trial in the context of a racially/ethnically diverse acute stroke service at University of Texas Southwestern (UTSW).
520			_aCONCLUSIONS: 3 main conclusions emerged: (a) The main limitations for inclusion in brain stimulation trials of motor recovery were magnitude of UE motor impairments and stroke lesion characteristics, (b) most stroke patients could be stimulated with tDCS without safety concerns and (c) carefully tailored inclusion criteria could increase diversity in enrollment.Clinical Trial Registration-URL: http://clinicaltrials.gov. Unique identifier: NCT01007136.
520			_aMETHODS: 3124 (59.7 +/- 14.5 years) racially/ethnically diverse (38.4% non-Hispanic white, (W), Hispanic (H) 22%, African American (AA) 33.5%, Asian (A) 2.3%) patients were screened in the acute stroke service at UTSW. Demographics, stroke characteristics, and reasons for exclusion were recorded prospectively.
520			_aRESULTS: 2327 (74.5%) patients had a verified stroke. Only 44 of them (1.9%) were eligible. Causes for exclusion included in order of importance: (1) magnitude of upper extremity (UE) motor impairment, (2) prior strokes (s), (3) hemorrhagic stroke, (4) psychiatric condition or inability to follow instructions, and (5) old age, of these (2) and (4) were more common in AA patients but not in other minorities. 31 of the 44 eligible individuals were enrolled (W 1.68%, H 1.37%, AA .77%, A 3.774%). 90.5% of verified stroke patients did not exhibit contraindications for stimulation.
546			_aEnglish
650			_aIN PROCESS -- NOT YET INDEXED
651			_aMedStar National Rehabilitation Network
657			_aJournal Article
700			_aDromerick, Alexander W
790			_aCohen LG, Dromerick AW, Hodics T, Kowalske K, Pezzullo JC
856			_uhttps://dx.doi.org/10.1177/15459683221088861 _zhttps://dx.doi.org/10.1177/15459683221088861
858			_yHodics, Timea _uhttps://orcid.org/0000-0001-8957-7807 _zhttps://orcid.org/0000-0001-8957-7807
942			_cART _dArticle
999			_c10910 _d10910