000			02982nam a22003617a 4500
008			211101s20212021 xxu||||| |||| 00| 0 eng d
022			_a1750-4589
040			_aOvid MEDLINE(R)
099			_a34301162
245			_aThe risks and benefits of early venous thromboembolism prophylaxis after elective spinal surgery: A single-centre experience.
251			_aJournal of Perioperative Practice. :17504589211002070, 2021 Jul 23
252			_aJ Perioper Pract. :17504589211002070, 2021 Jul 23
253			_aJournal of perioperative practice
260			_c2021
260			_fFY2022
265			_saheadofprint
266			_d2021-11-01
520			_aBACKGROUND: There is a wide ranging incidence of venous thromboembolism after surgery and it continues to be a major cause of morbidity after spinal procedures. This study's aim was to investigate the relationship between timing and administration of venous thromboembolism (VTE) pharmacologic chemoprophylaxis after spinal surgery and the resulting VTE and bleeding complications by reviewing current practices and outcomes at a high-volume single institution to better define opportunities for perioperative intervention to prevent VTE without increasing bleeding complications.
520			_aCONCLUSION: Patients undergoing elective spinal surgery who received anticoagulation within 24h of the conclusion of their procedure had an 81% reduction in the odds of developing a deep vein thrombosis within 30 days with no significant difference in bleeding complications.
520			_aMETHODS: All patients who underwent elective one or two-stage lumbar spinal fusion procedures were identified. A logistic regression was used to evaluate (1) risk of symptomatic VTE within 30 days of surgery and (2) bleeding-related complications. The odds of developing a VTE as well as bleeding-related complications were compared among the three treatment groups: no chemoprophylaxis, chemoprophylaxis < 24h of surgery and chemoprophylaxis given > 24h post-surgery.
520			_aRESULTS: When adjusted for doses administered, the odds of developing a postoperative VTE within 30 days were 0.189 (95% confidence interval (0.044, 0.808)) in patients who received anticoagulation < 24h postoperatively, compared to those who received no anticoagulation (p = 0.025). There was no difference in bleeding rates.
546			_aEnglish
650			_aIN PROCESS -- NOT YET INDEXED
651			_aMedStar Washington Hospital Center
656			_aSurgery/Vascular Surgery
657			_aJournal Article
700			_aKiguchi, Misaki M
700			_aWoo, Edward Y
790			_aEarls B, Freedman E, Ives AL, Kiguchi MM, Mo F, Pan-Chen S, Rungkitwattanakul D, Schobel H, TenEyck E, Woo EY
856			_uhttps://dx.doi.org/10.1177/17504589211002070 _zhttps://dx.doi.org/10.1177/17504589211002070
858			_yKiguchi, Misaki M _uhttps://orcid.org/0000-0001-6132-6408 _zhttps://orcid.org/0000-0001-6132-6408
942			_cART _dArticle
999			_c11236 _d11236