000			03357nam a22004337a 4500
008			230626s20232023 xxu||||| |||| 00| 0 eng d
022			_a0974-8237
024			_a10.4103/jcvjs.jcvjs_127_22 [doi]
024			_aJCVJS-14-24 [pii]
024			_aPMC10198216 [pmc]
040			_aOvid MEDLINE(R)
099			_a37213579
245			_aNeurosurgical management of patients with Ehlers-Danlos syndrome: A descriptive case series.
251			_aJournal of Craniovertebral Junction & Spine. 14(1):24-34, 2023 Jan-Mar.
252			_aJ Craniovertebr Junction Spine. 14(1):24-34, 2023 Jan-Mar.
253			_aJournal of craniovertebral junction & spine
260			_c2023
260			_fFY2023
260			_p2023 Jan-Mar
265			_sppublish
265			_tPubMed-not-MEDLINE
266			_d2023-06-26
520			_aConclusions: EDS patients are prone to instability, especially in the occipital-cervical region, which may predispose these patients to require a higher rate of revision procedures and may require modifications in neurosurgical management that should be further explored. Copyright: © 2023 Journal of Craniovertebral Junction and Spine.
520			_aIntroduction: Ehlers-Danlos syndrome (EDS) is a connective tissue disorder that has been linked to several neurological problems including Chiari malformations, atlantoaxial instability (AAI), craniocervical instability (CCI), and tethered cord syndrome. However, neurosurgical management strategies for this unique population have not been well-explored to date. The purpose of this study is to explore cases of EDS patients who required neurosurgical intervention to better characterize the neurological conditions they face and to better understand how neurosurgeons should approach the management of these patients.
520			_aMethods: A retrospective review was done on all patients with a diagnosis of EDS who underwent a neurosurgical operation with the senior author (FAS) between January 2014 and December 2020. Demographic, clinical, operative, and outcome data were collected, with additional radiographic data collected on patients chosen as case illustrations.
520			_aResults: Sixty-seven patients were identified who met the criteria for this study. The patients experienced a wide array of preoperative diagnoses, with Chiari malformation, AAI, CCI, and tethered cord syndrome representing the majority. The patients underwent a heterogeneous group of operations with the majority including a combination of the following procedures- suboccipital craniectomy, occipitocervical fusion, cervical fusion, odontoidectomy, and tethered cord release. The vast majority of patients experienced subjective symptomatic relief from their series of procedures.
546			_aEnglish
650			_zAutomated
651			_aMedStar Washington Hospital Center
656			_aMedStar Georgetown University Hospital/MedStar Washington Hospital Center
656			_aNeurosurgery
656			_aNeurosurgery Residency
657			_aJournal Article
700			_aFelbaum, Daniel _bMWHC
700			_aZhao, David _bMGUH _cNeurosurgery Residency _dMD _eResident PGY 6
790			_aRock MB, Zhao DY, Felbaum DR, Sandhu FA
856			_uhttps://dx.doi.org/10.4103/jcvjs.jcvjs_127_22 _zhttps://dx.doi.org/10.4103/jcvjs.jcvjs_127_22
942			_cART _dArticle
999			_c12552 _d12552