000			03599nam a22003977a 4500
008			230721s20232023 xxu||||| |||| 00| 0 eng d
022			_a2405-8440
024			_a10.1016/j.heliyon.2023.e17395 [doi]
024			_aPMC10277255 [pmc]
024			_aS2405-8440(23)04603-0 [pii]
040			_aOvid MEDLINE(R)
099			_a37366529
245			_aCardiac evaluation of hospitalized children with 2019 coronavirus (COVID-19) infection at a single large quaternary center.
251			_aHeliyon. 9(6):e17395, 2023 Jun.
252			_aHeliyon. 9(6):e17395, 2023 Jun.
253			_aHeliyon
260			_c2023
260			_fFY2023
260			_p2023 Jun
265			_sppublish
265			_tPubMed-not-MEDLINE
266			_d2023-07-21
520			_aBackground: Cardiac complications of serious SARS-CoV-2 infections, especially Multisystem Inflammatory Syndrome of Children (MIS-C) are well described, however current studies have not considered pediatric patients hospitalized with no cardiac concerns. We established a protocol for cardiac evaluation of all admitted COVID-19 patients three weeks post-discharge, irrespective of cardiac concerns. We assessed cardiovascular outcomes and hypothesized that patients with absent cardiac concerns are at lower risk for cardiac abnormalities.
520			_aConclusion: Cardiac abnormalities were found in pediatric patients admitted with COVID-19, even those without apparent cardiovascular concerns. The risk was greatest in ICU-admitted patients with cardiac concerns. The clinical significance of diastolic function assessment in these patients remains unknown. Further studies are needed to assess long-term cardiovascular sequelae of children with COVID-19, irrespective of cardiac concerns. Copyright © 2023 The Authors.
520			_aMethods: This was a retrospective study of 160 patients admitted for COVID-19 (excluding MIS-C) between March 2020 and September 2021 with subsequent echocardiogram(s) performed at our center. Patients were divided into 4 subgroups: Group 1 included patients with absent cardiac concerns, admitted to acute care (1a) and intensive care unit (ICU) (1 b). Group 2 included patients with cardiac concerns, admitted to acute care (2a) and ICU (2 b). Groups were compared based on clinical endpoints and echocardiographic measurements, including tissue Doppler imaging (TDI) assessment of diastolic function (z-score of septal Mitral E/TDI E' and lateral E/TDI E'). Chi-squared, Fisher's exact, and Kruskal-Wallis tests were used.
520			_aResults: Traditional cardiac abnormalities varied significantly between the groups; with Group 2 b having the most (n = 8, 21%), but still found in Group 1a (n = 2, 3%) and Group 1 b (n = 1, 5%). No patients in Group 1 demonstrated abnormal systolic function, compared to Group 2a (n = 1, 3%) and Group 2 b (n = 3, 9%, p = 0.07). When including TDI assessment of diastolic function, the total incidence of abnormalities found on echocardiogram was increased in all groups.
546			_aEnglish
650			_zAutomated
656			_aMedStar Georgetown University Hospital/MedStar Washington Hospital Center
656			_aPediatrics Residency
657			_aJournal Article
700			_aNg, Qimin _bMGUH _cPediatrics Residency _dMD _eResident PGY 3
790			_aAnsusinha E, Berul CI, Bost JE, DeBiasi RL, Harahsheh AS, Loke YH, Lowndes RW, Mehrtens K, Ng Q, Schultz J, Sharron MP, Smith KL, Wessel D
856			_uhttps://dx.doi.org/10.1016/j.heliyon.2023.e17395 _zhttps://dx.doi.org/10.1016/j.heliyon.2023.e17395
942			_cART _dArticle
999			_c13009 _d13009